Fluorescent polymer nanoparticle-based drug delivery system for treatment of colorectal cancer by modulating RELL1

Colorectal cancer, a common cancer affecting the colon or rectum, poses a significant global health risk, often leading to severe complications and mortality. The likelihood of developing colorectal cancer rises with age, with most cases occurring in individuals over 50. To investigate the role of RELL1 in colon cancer progression, we analyzed the colon adenoma dataset GSE41657 from the Gene Expression Omnibus (GEO) and identified RELL1 as a key target for this study. We developed an innovative drug-loaded polymer fluorescent nanoparticle system, PEG-CS-FITC, which combines chitosan (CS) nanoparticles, polyethylene glycol (PEG), and fluorescein isothiocyanate (FITC). This nanoparticle platform encapsulated compound CP1 and was designed to deliver a newly synthesized therapeutic compound, resulting in the composite nanoparticle PEG-CS-FITC@CP1@1. Through biological testing, we assessed the impact of PEG-CS-FITC@CP1@1 on RELL1 expression in colorectal cancer cells. These findings establish a foundation for developing targeted therapies for colorectal cancer.