Strategies and methods of nanocrystal technology for targeting drug delivery

Nanocrystals is an important pharmaceutics approach to improve the drug efficacy of insoluble candidate compounds. However, the current nanocrystal-targeted delivery strategy and delivery efficiency are still difficult to fulfill the standard of clinical treatment. To provide reference for the targeted delivery of nanocrystals, the nanocrystal-targeting methods and efficiency was systematically commented. Furthermore, the effect of particle size on the targeted delivery of nanocrystals and the effect of the combination of nanocrystals with conventional dosage forms on the targeted delivery were also summarized. This review is conducive to promoting the development of nanocrystal-targeted delivery formulation technology, and provides reference for the methods of nanocrystal-targeted delivery.