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<p>The fundamental challenge in clinical practice is predicting whether patients with cognitive symptoms or impairment will improve or stay stable. Population ageing is a worldwide phenomena with various impacts. Among dementia, Alzheimer disease (AD) is common in the elderly which is the most common form of dementia and may contribute to 60–70% of cases. An early and precise AD diagnosis enhances patient quality of life. In this study, we propose an optimal group-wise non-rigid image registration technique for dementia (AD) prediction. We introduce an improved cuckoo search optimization (ICSO) algorithm to search optimal group-wise dense correspondence in large image sets in non-rigid image registration which reduce dimensionality of the search space. Then, we illustrate a teacher-student learning based optimization algorithm which cooperates with PLS regression to extract deformation which separates the relationship information suitable for each other from the raw relationship information. After that, we compute the distribution of morphologies of age by fitting smooth percentile curves to these scores using hybrid capsule neural network with least Median Square (hybrid CNN-LMS) curve fitting model. Finally, the simulation results of proposed hybrid CNN-LMS technique are compared to the existing methods to analyze the measures. We observed that the accuracy of our proposed hybrid CNN-LMS technique is 96.23% and 95.82% for RSS and ANDI datasets respectively.</p>

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An optimal group-wise non-rigid image registration technique based clinical decision support for dementia prediction

  • 期刊论文

  • 发表日期：

    2025年3月28日

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  • F. Sheeja Mary,
  • V. Asanambigai,
  • A. Lenin Fred

摘要

The fundamental challenge in clinical practice is predicting whether patients with cognitive symptoms or impairment will improve or stay stable. Population ageing is a worldwide phenomena with various impacts. Among dementia, Alzheimer disease (AD) is common in the elderly which is the most common form of dementia and may contribute to 60–70% of cases. An early and precise AD diagnosis enhances patient quality of life. In this study, we propose an optimal group-wise non-rigid image registration technique for dementia (AD) prediction. We introduce an improved cuckoo search optimization (ICSO) algorithm to search optimal group-wise dense correspondence in large image sets in non-rigid image registration which reduce dimensionality of the search space. Then, we illustrate a teacher-student learning based optimization algorithm which cooperates with PLS regression to extract deformation which separates the relationship information suitable for each other from the raw relationship information. After that, we compute the distribution of morphologies of age by fitting smooth percentile curves to these scores using hybrid capsule neural network with least Median Square (hybrid CNN-LMS) curve fitting model. Finally, the simulation results of proposed hybrid CNN-LMS technique are compared to the existing methods to analyze the measures. We observed that the accuracy of our proposed hybrid CNN-LMS technique is 96.23% and 95.82% for RSS and ANDI datasets respectively.