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Background <p>Cervical cancer (CC) persists as a major contributor to cancer-related deaths in the female population. Long non-coding RNAs have shown potential as biomarkers in tumors, but the function of DNM3OS in CC is unclear.</p> Objective <p>This study investigates the prognostic value of DNM3OS in CC and its functional effects in tumor cells, aiming to identify a promising biomarker for this cancer.</p> Methods <p>DNM3OS expression was measured in tumor and normal tissues from 152 patients with CC using RT-qPCR, and its association with progression-free survival and clinical parameters was analyzed. The role of DNM3OS on proliferation, invasion, apoptosis, and epithelial-mesenchymal transition (EMT) in CC cells was examined following overexpression or knockdown. The binding between miR-454-3p and DNM3OS was verified, and functional rescue experiments were conducted by upregulating miR-454-3p.</p> Results <p>DNM3OS was significantly downregulated in CC tissues, and its low expression was associated with larger tumor size, lymph node metastasis, and advanced FIGO stage. DNM3OS acted as an independent factor for prognosis, with its low expression correlating with poor progression-free survival in CC patients. DNM3OS directly bound to miR-454-3p. Overexpression of DNM3OS suppressed the proliferation, EMT, and invasion of CC cells, while promoting apoptosis. These antitumor effects were partially counteracted by miR-454-3p overexpression.</p> Conclusions <p>Downregulation of DNM3OS predicts poor prognosis in CC, and DNM3OS suppresses the biological behavior of tumor cells by sponging miR-454-3p. DNM3OS may serve as a prognostic biomarker for CC.</p>

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LncRNA DNM3OS suppresses proliferation, invasion, and epithelial-mesenchymal transition in cervical cancer cells via miR-454-3p

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • Xin Zheng,
  • Wenfang Wang,
  • Chao He,
  • Lu Wang

摘要

Background

Cervical cancer (CC) persists as a major contributor to cancer-related deaths in the female population. Long non-coding RNAs have shown potential as biomarkers in tumors, but the function of DNM3OS in CC is unclear.

Objective

This study investigates the prognostic value of DNM3OS in CC and its functional effects in tumor cells, aiming to identify a promising biomarker for this cancer.

Methods

DNM3OS expression was measured in tumor and normal tissues from 152 patients with CC using RT-qPCR, and its association with progression-free survival and clinical parameters was analyzed. The role of DNM3OS on proliferation, invasion, apoptosis, and epithelial-mesenchymal transition (EMT) in CC cells was examined following overexpression or knockdown. The binding between miR-454-3p and DNM3OS was verified, and functional rescue experiments were conducted by upregulating miR-454-3p.

Results

DNM3OS was significantly downregulated in CC tissues, and its low expression was associated with larger tumor size, lymph node metastasis, and advanced FIGO stage. DNM3OS acted as an independent factor for prognosis, with its low expression correlating with poor progression-free survival in CC patients. DNM3OS directly bound to miR-454-3p. Overexpression of DNM3OS suppressed the proliferation, EMT, and invasion of CC cells, while promoting apoptosis. These antitumor effects were partially counteracted by miR-454-3p overexpression.

Conclusions

Downregulation of DNM3OS predicts poor prognosis in CC, and DNM3OS suppresses the biological behavior of tumor cells by sponging miR-454-3p. DNM3OS may serve as a prognostic biomarker for CC.