Scholarlink

Background <p>Matrix Gla Protein (MGP) plays a critical role in vascular calcification and extracellular matrix regulation, processes implicated in cerebrovascular pathology. This study aimed to evaluate the potential association between two MGP gene single nucleotide polymorphisms (SNPs), G-7&#xa0;A (rs1800801) and T-138&#xa0;C (rs1800802), and susceptibility to ischemic stroke.</p> Methods and Results <p>A total of 230 individuals, including 115 patients with ischemic stroke and 115 healthy controls, were enrolled. Genomic DNA was extracted, and genotyping was performed using the PCR-RFLP method. Genotype and allele frequencies were statistically compared to assess their association with disease risk. No significant association was observed between the G-7&#xa0;A polymorphism and ischemic stroke under genotype distribution or genetic models (<i>p</i> = 0.33; allelic model OR: 0.77, 95% CI: 0.52–1.14). In contrast, the T-138&#xa0;C variant demonstrated statistically significant differences between groups (<i>p</i> = 0.015) and was associated with increased ischemic stroke risk under dominant (OR: 1.89, 95% CI: 1.12–3.19), recessive (OR: 3.54, 95% CI: 1.13–11.12), and allelic models (OR: 1.83, 95% CI: 1.20–2.78), suggesting a possible relationship with stroke susceptibility.</p> Conclusions <p>These findings indicate that the MGP T-138&#xa0;C polymorphism may contribute to ischemic stroke risk and could serve as a potential biomarker, whereas the G-7&#xa0;A variant appears to be unrelated to disease susceptibility. Further large-scale studies are needed to confirm these results. This is the first study to evaluate this association in a Turkish population.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The role of Matrix Gla Protein gene variants (G-7 A and T-138 C) in susceptibility to ischemic stroke: a case-control study

  • 期刊论文

  • 发表日期：

    2026年4月3日

查看全文
  • Mustafa Yildiz,
  • Damla Duru Kocer Kaya,
  • Hatice Segmen,
  • Tammam Sipahi,
  • Metin Budak

摘要

Background

Matrix Gla Protein (MGP) plays a critical role in vascular calcification and extracellular matrix regulation, processes implicated in cerebrovascular pathology. This study aimed to evaluate the potential association between two MGP gene single nucleotide polymorphisms (SNPs), G-7 A (rs1800801) and T-138 C (rs1800802), and susceptibility to ischemic stroke.

Methods and Results

A total of 230 individuals, including 115 patients with ischemic stroke and 115 healthy controls, were enrolled. Genomic DNA was extracted, and genotyping was performed using the PCR-RFLP method. Genotype and allele frequencies were statistically compared to assess their association with disease risk. No significant association was observed between the G-7 A polymorphism and ischemic stroke under genotype distribution or genetic models (p = 0.33; allelic model OR: 0.77, 95% CI: 0.52–1.14). In contrast, the T-138 C variant demonstrated statistically significant differences between groups (p = 0.015) and was associated with increased ischemic stroke risk under dominant (OR: 1.89, 95% CI: 1.12–3.19), recessive (OR: 3.54, 95% CI: 1.13–11.12), and allelic models (OR: 1.83, 95% CI: 1.20–2.78), suggesting a possible relationship with stroke susceptibility.

Conclusions

These findings indicate that the MGP T-138 C polymorphism may contribute to ischemic stroke risk and could serve as a potential biomarker, whereas the G-7 A variant appears to be unrelated to disease susceptibility. Further large-scale studies are needed to confirm these results. This is the first study to evaluate this association in a Turkish population.