Scholarlink

Background <p>Successful pregnancy requires a combination of factors, including a healthy embryo with high growth potential and an ideal intrauterine environment with appropriate hormonal levels [Dimitriadis E, Menkhorst E, Saito S, et al. in Nature reviews Disease primers 6(1): 98, 2020]. Abnormalities in maternal genetics and the correlated immune system negatively affect embryo implantation and subsequent placentation [Alecsandru D, Klimczak AM, Velasco JAG, Pirtea P, et al in Fertility and sterility 115(3): 561-566, 2021]. Given the central roles of trophoblast invasion, adhesion, and apoptosis in early placental development, dysregulation of key regulatory pathways may contribute to recurrent miscarriage (RM).</p> Method <p>Forty-three patients with a history of RM (age &lt;35) and 43 healthy controls of the same age were included in this case-control study. qRTPCR was used to estimate the expression of miR-410-5p, ITGA6, and BIRC7in chorionic villous samples. To complement these transcriptional findings, serum levels of ITGA6, livin, and caspase-3 were measured by ELISA. Clinical characteristics of both groups were evaluated.</p> Results <p>miR-410-5p expression was significantly higher, whereas ITGA6 and BIRC7 gene expression was lower in RM patients compared with controls. The patient group had significantly elevated levels of serum caspase-3 protein, which were inversely correlated with both BIRC7 gene expression and BIRC7 protein levels. These results indicate a potential link between elevated apoptosis in RM and dysregulation of the miR-410-5p/ITGA6 axis and BIRC7-related anti-apoptotic signaling pathways.ClinicalTrials.gov registration: NCT05658445</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Potential Role of MicroRNA-410-5p and BIRC7 Gene Pathways in Recurrent Miscarriage in an Egyptian Population

  • 期刊论文

  • 发表日期：

    2026年4月17日

查看全文
  • Nesma G. Farag,
  • Amany O. Mohamed,
  • Mahmoud Abdel-Aleem,
  • Thorya S. El-Deeb,
  • Shimaa A. Elghazally,
  • Mohamed G. Elnaggar,
  • Abdulmonem Al-Husseini,
  • Marwa A. Gaber

摘要

Background

Successful pregnancy requires a combination of factors, including a healthy embryo with high growth potential and an ideal intrauterine environment with appropriate hormonal levels [Dimitriadis E, Menkhorst E, Saito S, et al. in Nature reviews Disease primers 6(1): 98, 2020]. Abnormalities in maternal genetics and the correlated immune system negatively affect embryo implantation and subsequent placentation [Alecsandru D, Klimczak AM, Velasco JAG, Pirtea P, et al in Fertility and sterility 115(3): 561-566, 2021]. Given the central roles of trophoblast invasion, adhesion, and apoptosis in early placental development, dysregulation of key regulatory pathways may contribute to recurrent miscarriage (RM).

Method

Forty-three patients with a history of RM (age <35) and 43 healthy controls of the same age were included in this case-control study. qRTPCR was used to estimate the expression of miR-410-5p, ITGA6, and BIRC7in chorionic villous samples. To complement these transcriptional findings, serum levels of ITGA6, livin, and caspase-3 were measured by ELISA. Clinical characteristics of both groups were evaluated.

Results

miR-410-5p expression was significantly higher, whereas ITGA6 and BIRC7 gene expression was lower in RM patients compared with controls. The patient group had significantly elevated levels of serum caspase-3 protein, which were inversely correlated with both BIRC7 gene expression and BIRC7 protein levels. These results indicate a potential link between elevated apoptosis in RM and dysregulation of the miR-410-5p/ITGA6 axis and BIRC7-related anti-apoptotic signaling pathways.ClinicalTrials.gov registration: NCT05658445