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Background <p>NOS1AP/CAPON has been associated with neurological and cardiovascular diseases, but it has recently gained significant attention in cancer research. A limited number of studies conducted on breast cancer (BC) suggest that NOS1AP may possess both tumor suppressive and oncogenic potential.</p> Methods and results <p>This study is the first to investigate the relationship between NOS1AP and EMT (Epithelial-Mesenchymal Transition) in BC tissues and within distinct BC subtypes. Additionally, it provides a pioneering analysis of NOS1AP associations with Hippo pathway components across BC subtypes. The expression levels of NOS1AP, Hippo pathway genes, and EMT markers in primary tissues from different BC subtypes were analyzed using RT-PCR. While NOS1AP expression was reduced in basal BC tissues compared to normal adjacent tissues (NAT), in luminal B BC tissues, only NOS1AP and CDH1 expression showed a significant increase (<i>p</i> &lt; 0.05). Correlation analyses suggest a potential association between NOS1AP, EMT markers, and components of the Hippo pathway. Bioinformatics analysis of overall survival (OS) curves revealed that high NOS1AP expression is associated with prolonged OS, irrespective of BC subtype.</p> Conclusions <p>These findings suggest that NOS1AP may play a dual role in a subtype-specific manner, potentially serving as a subtype-specific biomarker.</p>

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NOS1AP: a potential subtype-specific dual role as a tumor suppressor and oncogene in breast cancer subtypes

  • 期刊论文

  • 发表日期：

    2025年10月23日

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  • Büşra Polat,
  • Gökçe Güllü Amuran,
  • İrem Peker Eyüboğlu,
  • Mustafa Ümit Uğurlu,
  • Handan Kaya,
  • Mustafa Akkiprik

摘要

Background

NOS1AP/CAPON has been associated with neurological and cardiovascular diseases, but it has recently gained significant attention in cancer research. A limited number of studies conducted on breast cancer (BC) suggest that NOS1AP may possess both tumor suppressive and oncogenic potential.

Methods and results

This study is the first to investigate the relationship between NOS1AP and EMT (Epithelial-Mesenchymal Transition) in BC tissues and within distinct BC subtypes. Additionally, it provides a pioneering analysis of NOS1AP associations with Hippo pathway components across BC subtypes. The expression levels of NOS1AP, Hippo pathway genes, and EMT markers in primary tissues from different BC subtypes were analyzed using RT-PCR. While NOS1AP expression was reduced in basal BC tissues compared to normal adjacent tissues (NAT), in luminal B BC tissues, only NOS1AP and CDH1 expression showed a significant increase (p < 0.05). Correlation analyses suggest a potential association between NOS1AP, EMT markers, and components of the Hippo pathway. Bioinformatics analysis of overall survival (OS) curves revealed that high NOS1AP expression is associated with prolonged OS, irrespective of BC subtype.

Conclusions

These findings suggest that NOS1AP may play a dual role in a subtype-specific manner, potentially serving as a subtype-specific biomarker.