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<p>Acute Ischemic Stroke, as a cerebrovascular disease with high mortality and disability rates worldwide, has a complex pathological mechanism and a narrow therapeutic window. After the onset of ischemia, the ischemic core area of the brain tissue rapidly infarcts due to irreversible damage, while the fate of neurons in the surrounding penumbra depends on the dynamic balance between stress adaptation and cumulative damage. In recent years, stress granules, key structures that enable cells to respond to stress, have become a focus of research regarding their dynamic phase transitions (liquid-liquid phase separation and liquid-solid phase separation) and their role in regulating neuronal fate. This article systematically reviews the biological characteristics of stress granules, their spatiotemporal dynamic patterns in Acute Ischemic Stroke, and their association with neuronal damage. Also, it explores potential therapeutic strategies targeting stress granules. </p> Graphical Abstract&#xa0; <p>Created in BioRender. Zhai, X. (2025) <a href="https://BioRender.com/xtcoh8q">https://BioRender.com/xtcoh8q</a>.</p> <p></p>

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Unveiling the Spatiotemporal dynamics of stress granule phase transition: A key mechanism governing neuronal fate in acute ischemic stroke

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Xianglong Zhai,
  • Qing Zhu,
  • Beibei Yao,
  • Peiyi Mo,
  • Zhaoyao Chen,
  • Wenlei Li,
  • Yuan Zhu,
  • Minghua Wu

摘要

Acute Ischemic Stroke, as a cerebrovascular disease with high mortality and disability rates worldwide, has a complex pathological mechanism and a narrow therapeutic window. After the onset of ischemia, the ischemic core area of the brain tissue rapidly infarcts due to irreversible damage, while the fate of neurons in the surrounding penumbra depends on the dynamic balance between stress adaptation and cumulative damage. In recent years, stress granules, key structures that enable cells to respond to stress, have become a focus of research regarding their dynamic phase transitions (liquid-liquid phase separation and liquid-solid phase separation) and their role in regulating neuronal fate. This article systematically reviews the biological characteristics of stress granules, their spatiotemporal dynamic patterns in Acute Ischemic Stroke, and their association with neuronal damage. Also, it explores potential therapeutic strategies targeting stress granules.

Graphical Abstract 

Created in BioRender. Zhai, X. (2025) https://BioRender.com/xtcoh8q.