Scholarlink

<p><i>Streptococcus bovis</i> is an opportunistic bacterium consistently associated with colorectal cancer (CRC). This article reviews previous experimental evidence that has successfully demonstrated the role of <i>S. bovis</i> species in the context of CRC. The emerging evidence from experimental studies shows that the development of CRC involves synergistic mechanisms. This includes microbial dysbiosis or bacterial factors, evasion of the host immune system leading to chronic inflammatory responses, and alterations in cellular signalling pathways, which together promote tumour development and progression. The review may contribute to a better understanding of the role of <i>S. bovis</i> in CRC and its potential as a microbial biomarker and cancer therapeutic target.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Exploring tumour-microbe interactions: in vitro and in vivo modelling of Streptococcus bovis-induced colorectal carcinogenesis

  • 期刊论文

  • 发表日期：

    2025年9月10日

查看全文
  • Khairiyah Murad,
  • Hassanain Al-Talib

摘要

Streptococcus bovis is an opportunistic bacterium consistently associated with colorectal cancer (CRC). This article reviews previous experimental evidence that has successfully demonstrated the role of S. bovis species in the context of CRC. The emerging evidence from experimental studies shows that the development of CRC involves synergistic mechanisms. This includes microbial dysbiosis or bacterial factors, evasion of the host immune system leading to chronic inflammatory responses, and alterations in cellular signalling pathways, which together promote tumour development and progression. The review may contribute to a better understanding of the role of S. bovis in CRC and its potential as a microbial biomarker and cancer therapeutic target.