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Objective <p>The goal of this study was to investigate the&#xa0;protective effects of abietic acid (AA) nanoparticles which were prepared using gamma-irradiation to ameliorate the nephrotoxicity induced by cisplatin (CP) in experimental mice.</p> Method <p>Forty eight mice were divided into eight groups (6 mice/group) as follows; control group I, group II (mice were received AA 40 mg/kg B.W.), group III (mice were received 40 mg/kg body weight AA nanoparticles), induction group IV (mice were injected with sole-dosage of CP), group V (mice were received 40 mg/kg body weight AA for 7 days, and at 7th day, they were injected with sole-dosage of CP), the other treated groups VI, VII, and VIII (mice were received 40, 20, and 10 mg/kg body weight AA nanoparticles respectively for one week and at 7th day, they were injected with single-dose of CP).</p> Results <p>Our findings exhibited that, with respect to the control group the CP induction group showed elevation in kidney functions (creatinine and urea). Additionally, the relative expression levels of nuclear factor kappa beta and caspase-3, as well as tissue levels of malondialdehyde, and interleukin-1β were significantly elevated, while tissue levels of total antioxidant capacity and glutathione were significantly decreased. The administration of AA or different doses of AA nanoparticles to mice prior to CP induction greatly attenuated the alterations that occurred in these parameters. In the induction group, the histological results revealed a unique pattern of kidney lesions, whereas the renal tissues in the treated groups before induction exhibited comparatively well-preserved construction. Pretreatment with AA nanoparticles (dose 40 mg/kg B.W) give the beast protective effect as indicated in almost biochemical parameters and histopathological investigation.</p> Conclusion <p>As evidenced by the biochemical and histological alterations, AA nanoparticles reduce functions of the kidney and oxidative stress as an effective scavenger of free radicals to either avoid or diminish the harmful impacts of CP. It may also offer significant protection against CP-induced renal inflammation and apoptosis.</p>

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Protective effect of abietic acid nanoparticles synthesized by gamma-irradiation against cisplatin-induced renal injury in mice: a promising novel natural nano-drug

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Mostafa Saif-Elnasr,
  • Doaa S. Salah-Eldin,
  • Alshimaa M. Elmalawany,
  • M. A. Elhady,
  • Heba K. Abdelhakim

摘要

Objective

The goal of this study was to investigate the protective effects of abietic acid (AA) nanoparticles which were prepared using gamma-irradiation to ameliorate the nephrotoxicity induced by cisplatin (CP) in experimental mice.

Method

Forty eight mice were divided into eight groups (6 mice/group) as follows; control group I, group II (mice were received AA 40 mg/kg B.W.), group III (mice were received 40 mg/kg body weight AA nanoparticles), induction group IV (mice were injected with sole-dosage of CP), group V (mice were received 40 mg/kg body weight AA for 7 days, and at 7th day, they were injected with sole-dosage of CP), the other treated groups VI, VII, and VIII (mice were received 40, 20, and 10 mg/kg body weight AA nanoparticles respectively for one week and at 7th day, they were injected with single-dose of CP).

Results

Our findings exhibited that, with respect to the control group the CP induction group showed elevation in kidney functions (creatinine and urea). Additionally, the relative expression levels of nuclear factor kappa beta and caspase-3, as well as tissue levels of malondialdehyde, and interleukin-1β were significantly elevated, while tissue levels of total antioxidant capacity and glutathione were significantly decreased. The administration of AA or different doses of AA nanoparticles to mice prior to CP induction greatly attenuated the alterations that occurred in these parameters. In the induction group, the histological results revealed a unique pattern of kidney lesions, whereas the renal tissues in the treated groups before induction exhibited comparatively well-preserved construction. Pretreatment with AA nanoparticles (dose 40 mg/kg B.W) give the beast protective effect as indicated in almost biochemical parameters and histopathological investigation.

Conclusion

As evidenced by the biochemical and histological alterations, AA nanoparticles reduce functions of the kidney and oxidative stress as an effective scavenger of free radicals to either avoid or diminish the harmful impacts of CP. It may also offer significant protection against CP-induced renal inflammation and apoptosis.