<p>Cilia are highly conserved and microtubule-based organelles protruding from the cell surface. Their assembly and growth are referred to as ciliogenesis. During ciliogenesis, the mother centriole transforms into a basal body, which serves as the template for the ciliary axoneme. Ciliary vesicles required for cilia formation are derived from the Golgi apparatus. Importantly, the physical proximity between the Golgi apparatus and the centrosome is necessary for ciliogenesis. Evidence indicates that programmed death ligand 1 (PD-L1) functions at the centrosome and Golgi apparatus. Its depletion promotes the accumulation of ciliary membrane trafficking proteins and the sensory receptor protein polycystin 2, triggering aberrant ciliogenesis and leading to the development of polycystic kidney disease (PKD). Accordingly, in this review, based on the intimate relationship between the centrosome, Golgi apparatus, and cilia, we summarize in detail the effects of centrosome and its-related proteins, Golgi apparatus and its-associated proteins and Golgi apparatus-centrosome interaction on ciliogenesis. Collectively, understanding the connection between the Golgi apparatus and centrosome provides crucial insights into ciliogenesis mechanisms. Targeting organelle interactions, especially Golgi apparatus-centrosome communication, may represent a promising therapeutic avenue for the prevention and treatment of ciliopathies.</p>