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Background <p>Ascending aortic aneurysms (AsAA) are progressive dilations of the aortic wall associated with pathological remodeling. Non-coding RNAs, including lncRNA H19 and miR-181a-3p, regulate vascular remodeling and inflammation, partly through modulation of the TGF-β signaling pathway.</p> Methods and results <p>This study compared the expression of H19, miR-181a-3p, and TGF-β in aortic tissues from 48 patients undergoing AsAA or multivessel coronary artery bypass grafting (mCABG). Aortic tissue samples were collected, and RNA was extracted for quantitative real-time PCR analysis. MiR-181a-3p expression was significantly lower in the AsAA group compared to the mCABG group (<i>p</i> = 0.004), while TGF-β expression was higher (<i>p</i> = 0.022). When adjusted for DM, the difference in TGF-β expression became insignificant and H19 expression showed no significant difference between AsAA and mCABG groups.</p> Conclusions <p>The decreased expression of miR-181a-3p in AsAA suggests its potential as a biomarker. Further studies are needed to explore its role in AsAA pathophysiology.</p>

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Expression patterns and clinical relevance of H19, miR-181a-3p, and TGF-β in ascending aortic aneurysms: a comparative analysis of human aortic tissue

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Fatma Hande Karpuzoğlu,
  • Recep Çalışkan,
  • Şefika Nur Gümüş,
  • Canan Küçükgergin,
  • Abdurrahman Fatih Aydın,
  • Eren Karpuzoğlu,
  • Cevdet Uğur Koçoğullari

摘要

Background

Ascending aortic aneurysms (AsAA) are progressive dilations of the aortic wall associated with pathological remodeling. Non-coding RNAs, including lncRNA H19 and miR-181a-3p, regulate vascular remodeling and inflammation, partly through modulation of the TGF-β signaling pathway.

Methods and results

This study compared the expression of H19, miR-181a-3p, and TGF-β in aortic tissues from 48 patients undergoing AsAA or multivessel coronary artery bypass grafting (mCABG). Aortic tissue samples were collected, and RNA was extracted for quantitative real-time PCR analysis. MiR-181a-3p expression was significantly lower in the AsAA group compared to the mCABG group (p = 0.004), while TGF-β expression was higher (p = 0.022). When adjusted for DM, the difference in TGF-β expression became insignificant and H19 expression showed no significant difference between AsAA and mCABG groups.

Conclusions

The decreased expression of miR-181a-3p in AsAA suggests its potential as a biomarker. Further studies are needed to explore its role in AsAA pathophysiology.