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<p>Diabetes mellitus (DM) is a chronic metabolic disease characterized by insulin resistance and hyperglycemia. Emerging evidence suggests that chronic inflammation is central to the development of diabetes and associated complications. Inflammasomes, multi-protein complexes, are key regulators of the innate immune response. The pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18) are released upon activation. This causes inflammation in DM. This review aims to explain the mechanisms leading to the activation of inflammasomes and the regulation of different inflammasome isoforms concerning DM and related complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy. We will also explore the impact of metabolic factors like hyperglycemia and insulin resistance on activating inflammasomes. A better understanding of the interplay between different inflammasome isoforms and DM can help develop novel therapeutic strategies that target inflammasome pathways for preventing and treating complications associated with diabetes.</p>

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Role of inflammasomes in diabetes mellitus: mechanisms, complications, and therapeutic potential

  • 期刊论文

  • 发表日期：

    2025年6月21日

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  • K. L. Milan,
  • Bhatnagar Megha,
  • K. M. Ramkumar

摘要

Diabetes mellitus (DM) is a chronic metabolic disease characterized by insulin resistance and hyperglycemia. Emerging evidence suggests that chronic inflammation is central to the development of diabetes and associated complications. Inflammasomes, multi-protein complexes, are key regulators of the innate immune response. The pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18) are released upon activation. This causes inflammation in DM. This review aims to explain the mechanisms leading to the activation of inflammasomes and the regulation of different inflammasome isoforms concerning DM and related complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy. We will also explore the impact of metabolic factors like hyperglycemia and insulin resistance on activating inflammasomes. A better understanding of the interplay between different inflammasome isoforms and DM can help develop novel therapeutic strategies that target inflammasome pathways for preventing and treating complications associated with diabetes.