Scholarlink

<p>Circular RNA (circRNA), a type of noncoding RNA, features a covalently closed circular structure lacking 5'–3' polarity and a polyadenylated tail. Its resistance to RNase R degradation endows it with greater stability and resilience than linear RNA, leading to a prolonged half-life. Recent research has highlighted the crucial role of circRNAs, especially circPRMT5, in diverse cancers. CircPRMT5 is generated by reverse splicing of exon 18 within a 682-nucleotide gene. In various cancer cells, elevated circPRMT5 expression is correlated with increased tumor cell proliferation, migration, and invasion abilities. It impacts tumor progression by regulating cell proliferation, migration, invasion, and chemotherapy resistance. This review comprehensively examines the expression patterns, mechanisms, and clinical potential of circPRMT5 in cancers such as breast, bladder, nonsmall cell lung, esophageal, thyroid, liver, colorectal, and gastric cancer. Overall, circPRMT5 shows promise as a biomarker and therapeutic target, providing valuable insights for future cancer research and treatment strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Circular RNA rising star: new findings of circPRMT5 in cancer

  • 期刊论文

  • 发表日期：

    2025年6月18日

查看全文
  • DuanZhong Chen,
  • CaiYan Yin,
  • Chao Li,
  • Jun He,
  • Peng Wu

摘要

Circular RNA (circRNA), a type of noncoding RNA, features a covalently closed circular structure lacking 5'–3' polarity and a polyadenylated tail. Its resistance to RNase R degradation endows it with greater stability and resilience than linear RNA, leading to a prolonged half-life. Recent research has highlighted the crucial role of circRNAs, especially circPRMT5, in diverse cancers. CircPRMT5 is generated by reverse splicing of exon 18 within a 682-nucleotide gene. In various cancer cells, elevated circPRMT5 expression is correlated with increased tumor cell proliferation, migration, and invasion abilities. It impacts tumor progression by regulating cell proliferation, migration, invasion, and chemotherapy resistance. This review comprehensively examines the expression patterns, mechanisms, and clinical potential of circPRMT5 in cancers such as breast, bladder, nonsmall cell lung, esophageal, thyroid, liver, colorectal, and gastric cancer. Overall, circPRMT5 shows promise as a biomarker and therapeutic target, providing valuable insights for future cancer research and treatment strategies.