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Background <p>Calcium (Ca<sup>2+</sup>) is the most plentiful mineral in the body that partakes in various signaling pathways, such as the growth of nerve cells during the embryonic period and in the transmission of nerve messages. Aberration in Ca<sup>2+</sup> homeostasis has been involved in the neuropsychiatric disorders.</p> Methods and results <p>We have investigated expression levels of <i>SLC1A1</i>, <i>SLC25A12</i>, and <i>ATP2B2</i> genes from Ca<sup>2+</sup> signaling pathway, in addition to their related lncRNAs in the blood of patients with schizophrenia. Our results revealed substantial differences in the expression of <i>ATP2B2</i>, <i>SLC1A1</i>, <i>SLC25A12</i>, and <i>lnc-MTR-1:1</i> between cases and controls. <i>SLC25A12</i> had the premier AUC value for distinction of schizophrenia patients from healthy controls. <i>SLC1A1</i> ranked second in terms of AUC value.</p> Conclusions <p>Cumulatively, we demonstrated aberrations in the expression of Ca<sup>2+</sup>-related genes in schizophrenia. These genes might be regarded as potential markers in schizophrenia.</p>

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Alteration in Ca2+ signaling-related genes in schizophrenia

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Mohammad Taheri,
  • Ashkan Pourtavakoli,
  • Vidasadat Seyyedesfahani,
  • Solat Eslami,
  • Arezou Sayad,
  • Soudeh Ghafouri-Fard

摘要

Background

Calcium (Ca2+) is the most plentiful mineral in the body that partakes in various signaling pathways, such as the growth of nerve cells during the embryonic period and in the transmission of nerve messages. Aberration in Ca2+ homeostasis has been involved in the neuropsychiatric disorders.

Methods and results

We have investigated expression levels of SLC1A1, SLC25A12, and ATP2B2 genes from Ca2+ signaling pathway, in addition to their related lncRNAs in the blood of patients with schizophrenia. Our results revealed substantial differences in the expression of ATP2B2, SLC1A1, SLC25A12, and lnc-MTR-1:1 between cases and controls. SLC25A12 had the premier AUC value for distinction of schizophrenia patients from healthy controls. SLC1A1 ranked second in terms of AUC value.

Conclusions

Cumulatively, we demonstrated aberrations in the expression of Ca2+-related genes in schizophrenia. These genes might be regarded as potential markers in schizophrenia.