Chrysin downregulates the expression of ADAMTS-4 in foam cells

期刊论文
发表日期：

2024年9月9日

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S. S. Aswani,
Sreelekshmi G. Jayan,
Mithra S. Mohan,
N. S. Aparna,
P. T. Boban,
K. Saja

摘要

Background

Chrysin, a polyphenolic compound, possesses antioxidant and anti-inflammatory properties. In this study, we investigated the effect of chrysin on the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), a protease enzyme involved in degrading extracellular matrix associated with atherosclerosis.

Methods and Results

We have studied the cell viability by MTT assay and foam cell formation by oil red O staining. The mRNA and protein expression of ADAMTS-4 was studied using quantitative polymerase chain reaction (qPCR) and Western blotting, respectively. Our study showed that chrysin significantly downregulates the expression of ADAMTS-4 in foam cells.

Conclusion

Chrysin’s ability to downregulate the expression of ADAMTS-4, a protease involved in degrading the extracellular matrix, bestows upon it a new therapeutic potential for managing atherosclerosis.