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<p>Biomedical imaging has become an essential tool in the field of early cancer diagnosis and treatment. It is of great significance to develop a method that can monitor tumor hypoxia in real time and maintain a good photodynamic therapy (PDT) effect under hypoxic conditions. To achieve this goal, here we designed and synthesized a novel water-soluble porphyrin derivative, PtTSPP. The photophysical properties of PtTSPP were comprehensively characterized by UV–Vis absorption spectroscopy and fluorescence emission. This porphyrin has an extremely large Stokes shift and red emission (λ<sub>em</sub> = 690&#xa0;nm), which can effectively reduce the interference of background fluorescence and is used for the fluorescence imaging of HeLa cells. PtTSPP has good water solubility, is not prone to aggregation, and has a high singlet oxygen quantum yield. It also exhibits low dark toxicity and excellent photocytotoxicity. These properties make PtTSPP a promising candidate reagent for biomedical imaging and photodynamic therapy.</p>

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Water-soluble platinum(II)-porphyrin based on oxygen response for cell hypoxia imaging

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Meng-Yan Chai,
  • Yu-Li Dang,
  • He Qin,
  • Li-Xia Xie,
  • Xin Zheng,
  • Lijie Liu,
  • Guoxing Liu,
  • Yu-Qiang Xiang,
  • Cao-Yuan Niu,
  • Sheng-Qiang Guo

摘要

Biomedical imaging has become an essential tool in the field of early cancer diagnosis and treatment. It is of great significance to develop a method that can monitor tumor hypoxia in real time and maintain a good photodynamic therapy (PDT) effect under hypoxic conditions. To achieve this goal, here we designed and synthesized a novel water-soluble porphyrin derivative, PtTSPP. The photophysical properties of PtTSPP were comprehensively characterized by UV–Vis absorption spectroscopy and fluorescence emission. This porphyrin has an extremely large Stokes shift and red emission (λem = 690 nm), which can effectively reduce the interference of background fluorescence and is used for the fluorescence imaging of HeLa cells. PtTSPP has good water solubility, is not prone to aggregation, and has a high singlet oxygen quantum yield. It also exhibits low dark toxicity and excellent photocytotoxicity. These properties make PtTSPP a promising candidate reagent for biomedical imaging and photodynamic therapy.