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<p>A bis(NHC) manganese-catalyzed protocol for facile benzylic alkylation of a diverse range of arenes has been successfully developed. This innovative method enables the efficient synthesis of various alkylated arenes, including formal sp<sup>2</sup> C3-mono-alkylated indenes, sp<sup>3</sup> C1, sp<sup>2</sup> C3-di-alkylated indenes and other sp<sup>3</sup> C–H alkylated arenes, all derived from commonly accessible primary and secondary alcohols. Central to this alkylation reaction is the bis(NHC) manganese catalyst, which plays a pivotal role in facilitating the transformation of simple alcohols into complex and valuable organic compounds.</p> Graphical abstract <p></p>

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Production of benzylic-alkylated arenes: a bis(N-heterocyclic carbene) manganese(I)-catalyzed alkylation strategy using alcohols

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Zhi Luo,
  • Shuangkun Zhang,
  • Enqi Bai,
  • Kasha Cai

摘要

A bis(NHC) manganese-catalyzed protocol for facile benzylic alkylation of a diverse range of arenes has been successfully developed. This innovative method enables the efficient synthesis of various alkylated arenes, including formal sp2 C3-mono-alkylated indenes, sp3 C1, sp2 C3-di-alkylated indenes and other sp3 C–H alkylated arenes, all derived from commonly accessible primary and secondary alcohols. Central to this alkylation reaction is the bis(NHC) manganese catalyst, which plays a pivotal role in facilitating the transformation of simple alcohols into complex and valuable organic compounds.

Graphical abstract