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<p>Aza-heterocycles serve as privileged scaffolds in antiviral drug discovery due to their versatile chemical tunability and broad-spectrum biological activities. Strategic structural modifications of these pharmacophores have emerged as a powerful approach to optimize therapeutic potential, enabling the development of novel bioactive agents. These nitrogen-containing heterocycles demonstrate remarkable pharmacological diversity, exhibiting efficacy as anti-inflammatory, antimicrobial, antidiabetic, and anticancer compounds, along with enzyme inhibitory and pesticidal properties. This review systematically evaluates 5- and 6-membered aza-heterocyclic systems with established antiviral profiles, highlighting structure–activity relationships. The synthesized insights will advance research in synthetic organic chemistry, medicinal chemistry, and pharmacological development of next-generation therapeutics.</p> Graphical abstract <p></p>

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Advancements in antiviral activity of aza-heterocyclic compounds: a review

  • 期刊论文

  • 发表日期：

    2025年9月19日

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  • Issam Ameziane El Hassani,
  • Khalid Karrouchi,
  • M’hammed Ansar

摘要

Aza-heterocycles serve as privileged scaffolds in antiviral drug discovery due to their versatile chemical tunability and broad-spectrum biological activities. Strategic structural modifications of these pharmacophores have emerged as a powerful approach to optimize therapeutic potential, enabling the development of novel bioactive agents. These nitrogen-containing heterocycles demonstrate remarkable pharmacological diversity, exhibiting efficacy as anti-inflammatory, antimicrobial, antidiabetic, and anticancer compounds, along with enzyme inhibitory and pesticidal properties. This review systematically evaluates 5- and 6-membered aza-heterocyclic systems with established antiviral profiles, highlighting structure–activity relationships. The synthesized insights will advance research in synthetic organic chemistry, medicinal chemistry, and pharmacological development of next-generation therapeutics.

Graphical abstract