Scholarlink

<p>The catalytic asymmetric Mannich reaction is a multicomponent reaction which affords <i>β</i>-amino carbonyl compounds by utilizing an aldehyde, a primary or secondary amine/ammonia, and a ketone. <i>β</i>-amino carbonyl scaffolds are crucial intermediates for the synthesis of naturally occurring bioactive compounds and their derivatives. The synthesized natural compounds exhibit a broad spectrum of biological activities including anti-fungal, anti-cancer, anti-bacterial, anti-HIV, anti-oxidant, and anti-inflammatory activities. Considering the significance of asymmetric Mannich reaction to access diverse biologically active natural products, its applications to afford the synthesis of naturally occurring alkaloids have been summarized here. This review article showcases the key role of asymmetric Mannich reaction in the synthesis of pharmaceutically potent naturally occurring alkaloids, i.e., indole alkaloids, monoterpenoid-indole alkaloids, diterpenoid alkaloids, iso-quinoline alkaloids, polyketide alkaloids, and pyrrolizidine alkaloids, etc., reported since 2015.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Asymmetric Mannich reaction enabled synthesis of alkaloids

  • 期刊论文

  • 发表日期：

    2025年9月9日

查看全文
  • Summaya Fatima,
  • Asim Mansha,
  • Samreen Gul Khan,
  • Syed Makhdoom Hussain,
  • Bushra Parveen,
  • Ameer Fawad Zahoor,
  • Aqsa Mushtaq,
  • Rabia Ashraf,
  • Aijaz Rasool Chaudhry,
  • Ahmad Irfan

摘要

The catalytic asymmetric Mannich reaction is a multicomponent reaction which affords β-amino carbonyl compounds by utilizing an aldehyde, a primary or secondary amine/ammonia, and a ketone. β-amino carbonyl scaffolds are crucial intermediates for the synthesis of naturally occurring bioactive compounds and their derivatives. The synthesized natural compounds exhibit a broad spectrum of biological activities including anti-fungal, anti-cancer, anti-bacterial, anti-HIV, anti-oxidant, and anti-inflammatory activities. Considering the significance of asymmetric Mannich reaction to access diverse biologically active natural products, its applications to afford the synthesis of naturally occurring alkaloids have been summarized here. This review article showcases the key role of asymmetric Mannich reaction in the synthesis of pharmaceutically potent naturally occurring alkaloids, i.e., indole alkaloids, monoterpenoid-indole alkaloids, diterpenoid alkaloids, iso-quinoline alkaloids, polyketide alkaloids, and pyrrolizidine alkaloids, etc., reported since 2015.