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<p>The 2-substituted benzimidazole has emerged as a promising heterocyclic compound in the field of drug design. In pursuit of more sustainable photocatalysts for 2-substituted benzimidazole synthesis, the method for coating Fe<sub>3</sub>O<sub>4</sub> with V-doped TiO<sub>2</sub> was presented. On the base of characterizing composition, morphology, and properties, the prepared nano-sized Fe<sub>3</sub>O<sub>4</sub>@V/TiO<sub>2</sub> composites were used as a heterogeneous photocatalyst to catalyze the synthesis of 2-substituted benzimidazoles under light. The photocatalyst Fe<sub>3</sub>O<sub>4</sub>@V/TiO<sub>2</sub> composites showed the enhanced photocatalytic activity compared to no V-doped Fe<sub>3</sub>O<sub>4</sub>@TiO<sub>2</sub>, being able to yield various 2-substituted benzimidazoles in moderate to good yield with recyclability and stability. A possible photocatalysis mechanism was investigated. It was evident that holes, singlet oxygen, and ·O<sub>2</sub>̄ radical played important roles in the synthesis of 2-substituted benzimidazole. Moreover, some of the obtained products were demonstrated excellent antibacterial activity.</p> Graphical abstract <p>2-Substituted benzimidazole derivatives were synthesized using the prepared Fe<sub>3</sub>O<sub>4</sub>@V/TiO<sub>2</sub> as a photocatalyst at room temperature under visible light, and their anti-<i>Mycobacterium tuberculosis</i> activity was evaluated.</p> <p></p>

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Nano-sized heterogeneous photocatalyst Fe3O4@V/TiO2-catalyzed synthesis and antimycobacterial evaluation of 2-substituted benzimidazoles

  • 期刊论文

  • 发表日期：

    2025年1月21日

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  • Lijian Bao,
  • Xiaodong Chen,
  • Yanli Li,
  • Guangyuan Zhu,
  • Jingjun Wang,
  • Mingyue Chen,
  • Xingyu Bian,
  • Qiang Gu,
  • Yumin Zhang,
  • Feng Lin

摘要

The 2-substituted benzimidazole has emerged as a promising heterocyclic compound in the field of drug design. In pursuit of more sustainable photocatalysts for 2-substituted benzimidazole synthesis, the method for coating Fe3O4 with V-doped TiO2 was presented. On the base of characterizing composition, morphology, and properties, the prepared nano-sized Fe3O4@V/TiO2 composites were used as a heterogeneous photocatalyst to catalyze the synthesis of 2-substituted benzimidazoles under light. The photocatalyst Fe3O4@V/TiO2 composites showed the enhanced photocatalytic activity compared to no V-doped Fe3O4@TiO2, being able to yield various 2-substituted benzimidazoles in moderate to good yield with recyclability and stability. A possible photocatalysis mechanism was investigated. It was evident that holes, singlet oxygen, and ·O2̄ radical played important roles in the synthesis of 2-substituted benzimidazole. Moreover, some of the obtained products were demonstrated excellent antibacterial activity.

Graphical abstract

2-Substituted benzimidazole derivatives were synthesized using the prepared Fe3O4@V/TiO2 as a photocatalyst at room temperature under visible light, and their anti-Mycobacterium tuberculosis activity was evaluated.