New frontiers in multicomponent mechanosynthesis for organic molecules: modern marvels

In the past, mechanochemical approaches in organic synthesis were largely overlooked, but their perception within the synthetic community has shifted in recent years, marking a trend toward becoming mainstream. Mechanochemical multicomponent organic synthesis has garnered significant interest from both the academic and industrial chemical sectors. The efficiency and environmental friendliness of procedures conducted through mechanical activation have established mechanical procedures as prominent green techniques. Notably, utilizing solid starting materials under mechanochemical conditions empowers the development of novel multicomponent reactions that are often unfeasible in traditional solution-based processes. This capability not only enhances the diversity of accessible organic compounds but also sparks new avenues for innovative synthetic strategies. This approach facilitates the effective fulfillment of sustainable chemistry goals. In this context, we emphasize the major progress and advancements in mechanochemical multicomponent reactions from 2017 to 2024. This article covers the foremost multicomponent mechanosynthesis for developing organic molecules through carbon–carbon and carbon–heteroatom coupling reactions and multicomponent mechanosynthesis for monocyclic and fused heterocycles.

Mechanochemical synthesis has become mainstream and valued for its efficiency and eco-friendliness in academia and industry. These methods enable novel multicomponent reactions with solid materials, enhancing the diversity of organic compounds and fostering innovative strategies for sustainable chemistry. Significant advancements from 2017 to 2024 include developments in carbon‒carbon and carbon–heteroatom coupling and the synthesis of various heterocycles through mechanochemical multicomponent reactions.