Copper (II) complex supported on magnetic nanoparticles as a novel nanocatalyst for the synthesis of imidazo[1,2-a]pyridines

Research on the synthesis of imidazo[1,2-a]pyridines has gained great importance among synthetic chemists because there have been numerous reports of their biological and medicinal activities. In this respect, we fabricated CuCl₂ immobilized on Fe₃O₄ nanoparticles modified with 1,10-phenanthroline-5,6-diol [Fe₃O₄@Diol/Phen-CuCl₂] and investigated its catalytic activity for the preparation of imidazo[1,2-a]pyridine derivatives through one-pot three-component reaction of 2-aminopyridines, aldehydes and terminal alkynes under ecofriendly conditions. FT-IR spectroscopy, EDX, SEM, TEM, XRD, TGA, VSM and ICP-OES techniques employed in order to identify the structure of the as-constructed Fe₃O₄@Diol/Phen-CuCl₂ nanocatalyst. This catalytic system has a series of advantages such as the synthesis of imidazo[1,2-a]pyridine products with high yields in suitable time, performing the reactions in an environmentally friendly solvent (PEG), easy preparation of the catalyst with a simple method, and the recyclability of the Fe₃O₄@Diol/Phen-CuCl₂ nanocatalyst.