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<p>Chlorpyrifos (CPF), an organophosphate pesticide, is a widely used pest control chemical. Unfortunately, pesticides are known to cause neuronal intoxication. Umbelliferone (UMB) is an antioxidant, anti-inflammatory, and neuroprotective phytochemical. We plan to investigate the effectiveness of UMB in treating CPF-induced neurotoxicity. In our investigation, rats were assigned to the control, 30&#xa0;mg/kg of UMB, 10&#xa0;mg/kg of untreated CPF, CPF + UMB (15&#xa0;mg/kg), and CPF + UMB (30&#xa0;mg/kg) groups. UMB reduced neuronal intoxication by lowering p-Tau/Tau and β-amyloid. UMB reduced CPF-induced neuronal oxidative damage by lowering MDA content and increasing GSH levels, mediated by downregulating Keap1 and upregulating Nrf2, HO-1, and SOD3. UMB decreased CPF-induced brain inflammation by lowering TNF-α and IL-6 levels by suppressing NF-κB and STAT3 activation and downregulating NLRP3 dose-dependently. Our findings indicated that UMB is a potentially effective treatment approach for reducing CPF-induced neuronal intoxication by restoring the balance between oxidants and antioxidants and reducing inflammatory responses in brain tissues.</p>

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Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals

  • 期刊论文

  • 发表日期：

    2025年9月20日

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  • Salwa Fares Ahmed,
  • Tarek Hamdy Abd-Elhamid,
  • Sarah Abdulaziz Alamer,
  • Mohammad Bani ismail,
  • Fares E. M. Ali,
  • Emad H. M. Hassanein,
  • Hanan S. Althagafy,
  • Amany Refaat Mahmoud

摘要

Chlorpyrifos (CPF), an organophosphate pesticide, is a widely used pest control chemical. Unfortunately, pesticides are known to cause neuronal intoxication. Umbelliferone (UMB) is an antioxidant, anti-inflammatory, and neuroprotective phytochemical. We plan to investigate the effectiveness of UMB in treating CPF-induced neurotoxicity. In our investigation, rats were assigned to the control, 30 mg/kg of UMB, 10 mg/kg of untreated CPF, CPF + UMB (15 mg/kg), and CPF + UMB (30 mg/kg) groups. UMB reduced neuronal intoxication by lowering p-Tau/Tau and β-amyloid. UMB reduced CPF-induced neuronal oxidative damage by lowering MDA content and increasing GSH levels, mediated by downregulating Keap1 and upregulating Nrf2, HO-1, and SOD3. UMB decreased CPF-induced brain inflammation by lowering TNF-α and IL-6 levels by suppressing NF-κB and STAT3 activation and downregulating NLRP3 dose-dependently. Our findings indicated that UMB is a potentially effective treatment approach for reducing CPF-induced neuronal intoxication by restoring the balance between oxidants and antioxidants and reducing inflammatory responses in brain tissues.