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<p>Circular RNAs (circRNAs) have been identified as vital regulators in a variety of cancers, including glioma.However, the role of circRNAs in glioma initiation and progression remains largely unclear. In this study, we investigated the expression profiles of circRNA in three paired samples of glioblastoma multiforme (GBM). Our findings revealed that circSH3GL3 is significantly downregulated in GBM tissues, and its downregulation is associated with the WHO grade and patient survival. Furthermore, our research demonstrated that elevated circSH3GL3 suppresses cell proliferation and invasion both in vitro and in vivo. Mechanistically, circSH3GL3 shares microRNA response elements with tissue inhibitor of metalloproteinase 3 (TIMP3) and smad family member 7 (SMAD7).The present study investigates the role of circSH3GL3 in glioma proliferation and invasion. It is demonstrated that circSH3GL3 competitively binds to miR-21-5p, thereby preventing the decrease in the levels of TIMP3 and SMAD7. These proteins subsequently regulate the PI3K/AKT and Wnt/β-catenin signaling pathways, respectively. These findings reveal the critical role of circSH3GL3 in inhibiting glioma proliferation and invasion via a ceRNA mechanism. The study concludes that circSH3GL3 is a valuable biomarker and therapeutic target for glioma patients.</p>

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circSH3GL3 inhibits glioma progression and invasion via regulating the PI3K/AKT and Wnt/β-catenin signaling pathways by competitively binding with miR-21-5p

  • 期刊论文

  • 发表日期：

    2026年1月27日

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  • Yinrui Liu,
  • Zihao Liu,
  • Meixiang Wang,
  • Zhiyue Li,
  • Xianyong Yin,
  • Yuming Li,
  • Kailiang Zhang,
  • Shengjie Li,
  • Jing Wu,
  • Jikui Sun,
  • Feng Jin,
  • Tao Xin

摘要

Circular RNAs (circRNAs) have been identified as vital regulators in a variety of cancers, including glioma.However, the role of circRNAs in glioma initiation and progression remains largely unclear. In this study, we investigated the expression profiles of circRNA in three paired samples of glioblastoma multiforme (GBM). Our findings revealed that circSH3GL3 is significantly downregulated in GBM tissues, and its downregulation is associated with the WHO grade and patient survival. Furthermore, our research demonstrated that elevated circSH3GL3 suppresses cell proliferation and invasion both in vitro and in vivo. Mechanistically, circSH3GL3 shares microRNA response elements with tissue inhibitor of metalloproteinase 3 (TIMP3) and smad family member 7 (SMAD7).The present study investigates the role of circSH3GL3 in glioma proliferation and invasion. It is demonstrated that circSH3GL3 competitively binds to miR-21-5p, thereby preventing the decrease in the levels of TIMP3 and SMAD7. These proteins subsequently regulate the PI3K/AKT and Wnt/β-catenin signaling pathways, respectively. These findings reveal the critical role of circSH3GL3 in inhibiting glioma proliferation and invasion via a ceRNA mechanism. The study concludes that circSH3GL3 is a valuable biomarker and therapeutic target for glioma patients.