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<p>Chronic kidney disease (CKD) is a comprehensive disease characterized by renal injury and decreased renal function, which can lead to increased cardiovascular and all cause mortality rates, seriously affecting the quality of life and lifespan of patients. At present, although renal function decline can be treated with hormone drugs and immunosuppressive drugs, these treatment methods have not shown any beneficial effects on preventing CKD from progressing to renal failure. Dietary intervention has always been one of the cornerstones of CKD treatment, and nephrologists use dietary intervention to reduce symptoms and metabolic complications of CKD and potentially prevent its progression. This review discusses the relationship between kidney disease and amino acids. In addition, we emphasize the regulatory role of amino acid signaling pathways in the progression of CKD, with a focus on causal relationships and potential mechanisms.</p>

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The role of amino acid signaling in pathogenesis of chronic kidney disease

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Siya Yan,
  • Xiangqi Zhang,
  • Ruizhen Bu,
  • Ge Li,
  • Yang Wang,
  • Meifang Cheng,
  • Qian Chen,
  • Yuzheng Wu,
  • Yi Zhang,
  • Dan Wang,
  • Tao Wang

摘要

Chronic kidney disease (CKD) is a comprehensive disease characterized by renal injury and decreased renal function, which can lead to increased cardiovascular and all cause mortality rates, seriously affecting the quality of life and lifespan of patients. At present, although renal function decline can be treated with hormone drugs and immunosuppressive drugs, these treatment methods have not shown any beneficial effects on preventing CKD from progressing to renal failure. Dietary intervention has always been one of the cornerstones of CKD treatment, and nephrologists use dietary intervention to reduce symptoms and metabolic complications of CKD and potentially prevent its progression. This review discusses the relationship between kidney disease and amino acids. In addition, we emphasize the regulatory role of amino acid signaling pathways in the progression of CKD, with a focus on causal relationships and potential mechanisms.