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<p><i>MiR-150-5p</i> is a microRNA that plays an important role in the heart diseases. However, its specific role and molecular mechanism in heart failure (HF) remain unclear. In this study, we found that <i>miR-150-5p</i> was downregulated in patients with HF, while the expression of MMP14 was elevated. In vitro experiments have shown that <i>miR-150-5p</i> directly targets MMP14 and inhibits its expression in human aortic smooth muscle cells (HASMCs). Functionally, <i>miR-150-5p</i> promotes the proliferation, migration and apoptosis of HASMC, which is a key process in the progression of HF. In the HF mouse model induced by transverse aortic contraction (TAC), overexpression of <i>miR-150-5p</i> can improve cardiac function, reduce hypertrophy and fibrosis, while its inhibition aggravates these effects. These findings determined that <i>miR-150-5p</i> is a protective regulator in HF, functioning by inhibiting MMP14, and indicated its potential as a therapeutic target for HF treatment.</p>

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MiR-150-5p attenuates heart failure by targeting MMP14 to regulate vascular smooth muscle cell function

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月21日

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  • Xu Yu,
  • Yang Zhao,
  • Qikui Wang,
  • Xin Jiang,
  • Liang Zhang

摘要

MiR-150-5p is a microRNA that plays an important role in the heart diseases. However, its specific role and molecular mechanism in heart failure (HF) remain unclear. In this study, we found that miR-150-5p was downregulated in patients with HF, while the expression of MMP14 was elevated. In vitro experiments have shown that miR-150-5p directly targets MMP14 and inhibits its expression in human aortic smooth muscle cells (HASMCs). Functionally, miR-150-5p promotes the proliferation, migration and apoptosis of HASMC, which is a key process in the progression of HF. In the HF mouse model induced by transverse aortic contraction (TAC), overexpression of miR-150-5p can improve cardiac function, reduce hypertrophy and fibrosis, while its inhibition aggravates these effects. These findings determined that miR-150-5p is a protective regulator in HF, functioning by inhibiting MMP14, and indicated its potential as a therapeutic target for HF treatment.