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<p>Natural polysaccharides are a potential therapy for cardiovascular diseases (CVDs) resulting from intestinal barrier injury. More studies on the protective effects of natural polysaccharides on intestinal barrier injury are being conducted, although the underlying mechanisms remain unknown. Thus, the objective of this paper is to discuss current research on natural polysaccharides to reduce the risk of CVDs by preventing intestinal barrier injury. In addition, the protective benefits of natural polysaccharides against CVDs are explored. Finally, the preliminary structure–activity relationship of natural polysaccharides was discussed, which provided the theoretical basis for the modification of lead compound. These natural polysaccharides can enhance the intestinal barrier function of the intestine, hence preventing the incidence and development of CVDs.</p>

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Natural polysaccharides with the reduction of intestinal barrier damage in cardiovascular diseases

  • 期刊论文

  • 发表日期：

    2025年7月13日

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  • Guo-chen Zhong,
  • Peng Zhou

摘要

Natural polysaccharides are a potential therapy for cardiovascular diseases (CVDs) resulting from intestinal barrier injury. More studies on the protective effects of natural polysaccharides on intestinal barrier injury are being conducted, although the underlying mechanisms remain unknown. Thus, the objective of this paper is to discuss current research on natural polysaccharides to reduce the risk of CVDs by preventing intestinal barrier injury. In addition, the protective benefits of natural polysaccharides against CVDs are explored. Finally, the preliminary structure–activity relationship of natural polysaccharides was discussed, which provided the theoretical basis for the modification of lead compound. These natural polysaccharides can enhance the intestinal barrier function of the intestine, hence preventing the incidence and development of CVDs.