The aim of this contribution is twofold. First, by performing the quadratic decomposition of q-Dunkl-Appell sequences, a new lowering q-differential operator \(\mathcal {K}_{q^2 ; \theta ;\kappa }\) (with \(\kappa =\pm \frac{1}{2}\) ) naturally emerges, as the two polynomial sequences lying in the principal diagonal are \(\mathcal {K}_{q^2 ; \theta ;\kappa }\) -Appell. Second, triggered by this result, after developing the concept of the \(\mathcal {K}_{q ; \theta ;\kappa }\) -Appell sequences, all the orthogonal \(\mathcal {K}_{q ; \theta ;\kappa }\) -Appell sequences are sought, which outcome was the Wall q-polynomials with parameter \(b=\frac{q^{1-\kappa }}{1-(q^{1/2}-1)\theta }\) (resp. the Little q-Laguerre polynomials with parameter \(\alpha =bq^{-1}\) ) – they are indeed the unique ones fulfilling both properties, up to a linear transformation. This leads to a new characterization of these polynomial sequences.