Background <p>Research has increasingly explored maternal resilience or protective factors that enable women to achieve healthier maternal and child outcomes. However, it has not adequately examined maternal resilience using a culturally-relevant, socio-ecological lens or how it may be influenced by early-life stressors and resources. The current study contributes to the literature on maternal resilience by qualitatively exploring the salient multi-level stressors and resources experienced over the lifecourse by predominantly low-income and minoritized women.</p> Procedures <p>Data are from 19 women who were either adult mothers with children under 18 years of age living at home or reproductive-aged. Respondents completed semi-structured interviews, and grounded theory analyses identified themes related to stressors experienced and resilience resources utilized over the lifespan.</p> Results <p>Four domains relating to maternal stress and resilience, including <i>stressors</i> (caregiving stress, family conflict, and deaths in the family), <i>traumas</i> (abandonment, domestic violence, child abuse, and substance misuse), <i>coping mechanisms</i> (positive mindset, faith, activities, and movement, healthy eating, self-regulation, and self-love/care), and <i>supports</i> (family, friends, spouses/partners, community members, and religious institutions), emerged from the data. Familial relationships were perceived as the most significant support as well as the biggest source of stress and trauma.</p> Conclusions <p>As proposed by the socio-ecological framework, our findings suggest that components of maternal resilience exist at the individual (i.e., positive mindset, faith, self-regulation, self-love, and positive health behaviors), interpersonal (i.e., support from family, friends, and partner), and community (i.e., support from community members and religious organizations) levels.</p>