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Purpose <p>To critically examine peptide and peptide-functionalised hydrogels for wound repair through a sequence-assembly-mechanism-outcome framework, with emphasis on sequence-defined antimicrobial, wound-reparative and angiogenic systems.</p> Methods <p>Representative peer-reviewed primary studies and recent reviews were critically synthesised, focusing on exact peptide sequences or chemical modifications, their roles within hydrogel formulations, experimental models, demonstrated outcomes and evidential limitations.</p> Results <p>Sequence programming enables peptide hydrogels to combine extracellular-matrix-like structure with antimicrobial, cell-adhesive, enzyme-responsive or vascular-supportive functions. Key examples include Fmoc-FFKK, elastase-responsive RADA16-I constructs containing GHK, KGHK or RDKVYR, RGDC-containing click hydrogels, RADA-PRG, VEGF-mimetic RADA-KLT, HHC10 delivery systems and the NapFFTDDY carrier hydrogel. In vitro and animal studies support effects on biofilm control, cellular attachment, inflammation, angiogenic responses, granulation-tissue formation and wound closure. However, direct sequence-activity comparisons are uncommon, most platforms are multicomponent, and no human clinical wound-healing trial was identified among the representative sequence-defined systems reviewed.</p> Conclusion <p>Sequence-programmed peptide hydrogels are promising investigational wound-repair platforms rather than clinically established precision dressings. Translation requires rigorous mechanistic controls, reproducible manufacturing, sterilisation and storage validation, long-term safety assessment and comparison with established wound-care products.</p>

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Sequence-Programmed Peptide Hydrogels for Precision Wound Repair: From ECM Mimicry to Stage-Adaptive Bioactive Dressings

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Balaji Lakavath,
  • Mitali Singhal,
  • Prabhudas Nelaturi

摘要

Purpose

To critically examine peptide and peptide-functionalised hydrogels for wound repair through a sequence-assembly-mechanism-outcome framework, with emphasis on sequence-defined antimicrobial, wound-reparative and angiogenic systems.

Methods

Representative peer-reviewed primary studies and recent reviews were critically synthesised, focusing on exact peptide sequences or chemical modifications, their roles within hydrogel formulations, experimental models, demonstrated outcomes and evidential limitations.

Results

Sequence programming enables peptide hydrogels to combine extracellular-matrix-like structure with antimicrobial, cell-adhesive, enzyme-responsive or vascular-supportive functions. Key examples include Fmoc-FFKK, elastase-responsive RADA16-I constructs containing GHK, KGHK or RDKVYR, RGDC-containing click hydrogels, RADA-PRG, VEGF-mimetic RADA-KLT, HHC10 delivery systems and the NapFFTDDY carrier hydrogel. In vitro and animal studies support effects on biofilm control, cellular attachment, inflammation, angiogenic responses, granulation-tissue formation and wound closure. However, direct sequence-activity comparisons are uncommon, most platforms are multicomponent, and no human clinical wound-healing trial was identified among the representative sequence-defined systems reviewed.

Conclusion

Sequence-programmed peptide hydrogels are promising investigational wound-repair platforms rather than clinically established precision dressings. Translation requires rigorous mechanistic controls, reproducible manufacturing, sterilisation and storage validation, long-term safety assessment and comparison with established wound-care products.