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Background <p>Antimicrobial resistance (AMR) remains a major challenge in the treatment ofwound infections, particularly those involving multidrug-resistant bacteria. Antimicrobial peptides (AMPs) have attracted attention as potentialalternatives to conventional antibiotics; however, individual peptides may exhibit a limited spectrum of activity or undesirable cytotoxicity.Combining AMPs has been suggested as a possible approach to improve efficacy and selectivity</p> Findings <p>In this study, two cationic α-helicalAMPs, MP1-Q12K and BP52, were evaluated individually and in combination. While each peptide exhibited selective antibacterial activity, theircombination showed improved inhibitory effects against Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa compared tosingle treatments. Notably, co-administration did not increase hemolytic activity and showed a slight reduction at higher concentrations. Thepeptides were further incorporated into a film-forming hydrogel spray, which demonstrated sustained antibacterial activity and limited bacterialregrowth under the tested conditions.</p> Conclusion <p>These findings suggest that combining structurally distinct AMPs may enhance antibacterialactivity while maintaining an acceptable safety profile. The incorporation into a topical formulation indicates potential for further developmentas an alternative approach for managing wound-associated infections.</p> Graphical Abstract <p></p>

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Co-administration of Antimicrobial Peptides: A Promising Strategy to Broaden Antibacterial Activity and Minimize Hemolysis

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Phuong Dang Khanh,
  • Hai Bui Thi Phuong,
  • Khanh Nguyen Van,
  • Trung Hoang Trinh,
  • Hang Ngo Thu,
  • Mao Can Van,
  • Hiep Tran Tuan,
  • Oanh Nguyen Thi Kieu,
  • Huy Luong Xuan

摘要

Background

Antimicrobial resistance (AMR) remains a major challenge in the treatment ofwound infections, particularly those involving multidrug-resistant bacteria. Antimicrobial peptides (AMPs) have attracted attention as potentialalternatives to conventional antibiotics; however, individual peptides may exhibit a limited spectrum of activity or undesirable cytotoxicity.Combining AMPs has been suggested as a possible approach to improve efficacy and selectivity

Findings

In this study, two cationic α-helicalAMPs, MP1-Q12K and BP52, were evaluated individually and in combination. While each peptide exhibited selective antibacterial activity, theircombination showed improved inhibitory effects against Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa compared tosingle treatments. Notably, co-administration did not increase hemolytic activity and showed a slight reduction at higher concentrations. Thepeptides were further incorporated into a film-forming hydrogel spray, which demonstrated sustained antibacterial activity and limited bacterialregrowth under the tested conditions.

Conclusion

These findings suggest that combining structurally distinct AMPs may enhance antibacterialactivity while maintaining an acceptable safety profile. The incorporation into a topical formulation indicates potential for further developmentas an alternative approach for managing wound-associated infections.

Graphical Abstract