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Background <p> This study evaluated the clinical efficacy and safety of a low-molecular-weight&#xa0;collagen&#xa0;peptides&#xa0;(GPVGPS&#xa0;Collagen®) supplement in adults with damaged hair. The investigational product was obtained from the scales of <i>Oreochromis niloticus</i> via enzymatic hydrolysis.</p> Methods <p> A total of 100 adults (men and women aged 19–60&#xa0;years) with mild-to-moderate hair damage were randomized to receive GPVGPS Collagen® (2,000&#xa0;mg/day) or placebo once daily for 24&#xa0;weeks. The primary endpoints were changes in hair luster and mechanical properties at week 24 compared with baseline, along with safety assessments.</p> Results <p> Compared with placebo, the GPVGPS Collagen® group showed significant improvements in dermatologist-assessed and instrumentally measured (SAMBA) hair luster, hair shaft surface integrity, tensile strength, and diameter. Hair density and participant-reported satisfaction were also significantly greater in the treatment group. No safety-related adverse events were observed.</p> Conclusion <p> These findings demonstrate that daily GPVGPS Collagen® supplementation is clinically effective and safe for improving overall hair health, including luster, strength, thickness, and density.</p>

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Low-Molecular-Weight Collagen Peptides Improve Hair Health in Adults with Damaged Hair: A Randomized, Double-Blind, Placebo-Controlled Trial

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Yu-ri Gwon,
  • AReum Kim,
  • Mi Hye Seo,
  • Ji-Hae Lee,
  • Jin Hee Shin,
  • Hae Kwang Lee,
  • Byung Cheol Park,
  • Joon Seok,
  • Beom Joon Kim,
  • Jinhak Kim,
  • Miyoung Park

摘要

Background

This study evaluated the clinical efficacy and safety of a low-molecular-weight collagen peptides (GPVGPS Collagen®) supplement in adults with damaged hair. The investigational product was obtained from the scales of Oreochromis niloticus via enzymatic hydrolysis.

Methods

A total of 100 adults (men and women aged 19–60 years) with mild-to-moderate hair damage were randomized to receive GPVGPS Collagen® (2,000 mg/day) or placebo once daily for 24 weeks. The primary endpoints were changes in hair luster and mechanical properties at week 24 compared with baseline, along with safety assessments.

Results

Compared with placebo, the GPVGPS Collagen® group showed significant improvements in dermatologist-assessed and instrumentally measured (SAMBA) hair luster, hair shaft surface integrity, tensile strength, and diameter. Hair density and participant-reported satisfaction were also significantly greater in the treatment group. No safety-related adverse events were observed.

Conclusion

These findings demonstrate that daily GPVGPS Collagen® supplementation is clinically effective and safe for improving overall hair health, including luster, strength, thickness, and density.