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Objective <p>this study aimed to evaluate the efficacy of soybean meal bioactive peptides and acidified drinking water, individually or in combination, on growth performance, cecal microbial population, intestinal morphology, and welfare aspects in broiler chickens challenged with necrotic enteritis (NE).</p> Methodology <p>A total of 360 male broiler chicks with an average initial weight of 43 ± 1&#xa0;g were randomly distributed into six groups (with 5 replicates of 12 birds each). The experimental treatments were a negative control (NC, unchallenged), positive control (PC, challenged), PC + 0.5&#xa0;g/kg Zinc-Bacitracin (PCB); PC + 3&#xa0;ml/L acidifier in drinking water (PCA); PC + 5&#xa0;g/kg soybean meal bioactive peptides (PCP); and PC group with both 3&#xa0;ml/L acidifier in drinking water and 5&#xa0;g/kg dietary bioactive peptides (PCAP).</p> Results <p>During 1 to 42 days, supplementation with antibiotic (PCB), acidifier (PCA), and the combination of acidifier and soybean meal bioactive peptides (PCAP) improved body weight gain and feed conversion ratio to levels comparable to the NC group (<i>P</i> &lt; 0.05). Villus height and villus surface area were reduced (<i>P</i> &lt; 0.05) by NE (579.8&#xa0;μm and 0.15&#xa0;mm², respectively) but were restored in treated groups, especially PCAP (665.6&#xa0;μm and 0.19&#xa0;mm²). In microbial population, total bacteria were highest in the challenged birds (PC) and the lowest was observed in the PCA birds (<i>P</i> &lt; 0.05). <i>Lactobacillus</i> count was highest in the PCAP group compared to PCA and PC groups (<i>P</i> &lt; 0.05). Moreover, NE challenge increased the cecal enumeration of <i>Clostridium perfringens</i> (6.92 log CFU/g), which were reduced to 5.41–5.90 log CFU/g in treated and NC groups (<i>P</i> &lt; 0.05). The foot pad dermatitis (FPD) index, intestine lesion, and litter quality were ameliorated in NC and treated birds compared to the PC group (<i>P</i> &lt; 0.05).</p> Conclusions <p>These findings suggest that use of soybean meal bioactive peptides and water acidification, particularly in combination, can mitigate NE effects and serve as viable alternatives to antibiotic utilization in broiler production.</p>

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Efficacy of Soybean Meal Bioactive Peptides Individually or in Combination with Acidified Drinking Water on Growth performance, Gut Health, and Welfare Aspects in Broiler Chickens Under Necrotic Enteritis Challenge

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Hadi Mehdinejad Nouri,
  • Vahid Rezaeipour,
  • Rohullah Abdullahpour,
  • Saeed Seifi,
  • Rahem Khoshbakht

摘要

Objective

this study aimed to evaluate the efficacy of soybean meal bioactive peptides and acidified drinking water, individually or in combination, on growth performance, cecal microbial population, intestinal morphology, and welfare aspects in broiler chickens challenged with necrotic enteritis (NE).

Methodology

A total of 360 male broiler chicks with an average initial weight of 43 ± 1 g were randomly distributed into six groups (with 5 replicates of 12 birds each). The experimental treatments were a negative control (NC, unchallenged), positive control (PC, challenged), PC + 0.5 g/kg Zinc-Bacitracin (PCB); PC + 3 ml/L acidifier in drinking water (PCA); PC + 5 g/kg soybean meal bioactive peptides (PCP); and PC group with both 3 ml/L acidifier in drinking water and 5 g/kg dietary bioactive peptides (PCAP).

Results

During 1 to 42 days, supplementation with antibiotic (PCB), acidifier (PCA), and the combination of acidifier and soybean meal bioactive peptides (PCAP) improved body weight gain and feed conversion ratio to levels comparable to the NC group (P < 0.05). Villus height and villus surface area were reduced (P < 0.05) by NE (579.8 μm and 0.15 mm², respectively) but were restored in treated groups, especially PCAP (665.6 μm and 0.19 mm²). In microbial population, total bacteria were highest in the challenged birds (PC) and the lowest was observed in the PCA birds (P < 0.05). Lactobacillus count was highest in the PCAP group compared to PCA and PC groups (P < 0.05). Moreover, NE challenge increased the cecal enumeration of Clostridium perfringens (6.92 log CFU/g), which were reduced to 5.41–5.90 log CFU/g in treated and NC groups (P < 0.05). The foot pad dermatitis (FPD) index, intestine lesion, and litter quality were ameliorated in NC and treated birds compared to the PC group (P < 0.05).

Conclusions

These findings suggest that use of soybean meal bioactive peptides and water acidification, particularly in combination, can mitigate NE effects and serve as viable alternatives to antibiotic utilization in broiler production.