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Background <p>Currently, microalgae and cyanobacteria thrill the researchers with their wide range of applications and diverse health benefits. The bioactive peptides from microalgae and cyanobacteria are emerging as a promising alternative to synthetic drugs, especially in combating lifestyle-related diseases such as oxidative stress, diabetes, cancer, cardiovascular disorders, and microbial infections. These peptides have earned thoughtful importance nowadays due to their high value, specificity, and lack of side effects.</p> Purpose <p>This review aims to summarize the recent research on extraction, preparation, and purification of bioactive peptides produced through protein hydrolysis, ribosomal, and non-ribosomal synthesis from microalgae and cyanobacteria, with a focus on their therapeutic process and their mechanism of action.</p> Results <p>Peptides produced via protein hydrolysis and biosynthetic pathways from microalgae and cyanobacteria exhibit a broad spectrum of bioactivities, including antimicrobial, antioxidant, anti-inflammatory, anticancer, and angiotensin-converting enzyme (ACE) inhibitory properties.</p> Conclusion <p>Understanding the possible mechanism of action of the peptides, which is crucial for scientific knowledge, as it exposes how the interaction of molecules takes place at cellular and molecular levels to exert their therapeutic effects. Therefore, this insight is vital for developing novel and focused treatment plans, creating safe and efficient functional foods, and guaranteeing the safety of peptides in a range of applications.</p>

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Bioactive Peptides from Microalgae and Cyanobacteria and Their Possible Mechanisms of Action

  • 期刊论文

  • 发表日期：

    2025年7月31日

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  • Soundararajan Vishnu Chitthan,
  • Asraf Sithikka Rasheed,
  • Menaka Muniyandi,
  • Dharumadurai Dhanasekaran,
  • Nooruddin Thajuddin

摘要

Background

Currently, microalgae and cyanobacteria thrill the researchers with their wide range of applications and diverse health benefits. The bioactive peptides from microalgae and cyanobacteria are emerging as a promising alternative to synthetic drugs, especially in combating lifestyle-related diseases such as oxidative stress, diabetes, cancer, cardiovascular disorders, and microbial infections. These peptides have earned thoughtful importance nowadays due to their high value, specificity, and lack of side effects.

Purpose

This review aims to summarize the recent research on extraction, preparation, and purification of bioactive peptides produced through protein hydrolysis, ribosomal, and non-ribosomal synthesis from microalgae and cyanobacteria, with a focus on their therapeutic process and their mechanism of action.

Results

Peptides produced via protein hydrolysis and biosynthetic pathways from microalgae and cyanobacteria exhibit a broad spectrum of bioactivities, including antimicrobial, antioxidant, anti-inflammatory, anticancer, and angiotensin-converting enzyme (ACE) inhibitory properties.

Conclusion

Understanding the possible mechanism of action of the peptides, which is crucial for scientific knowledge, as it exposes how the interaction of molecules takes place at cellular and molecular levels to exert their therapeutic effects. Therefore, this insight is vital for developing novel and focused treatment plans, creating safe and efficient functional foods, and guaranteeing the safety of peptides in a range of applications.