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<p>Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are serious health concerns worldwide that require regular dialysis before a kidney transplant for a better quality of life. Due to aging and frailty, dialysis patients are often limited in physical activity, which can lead to multiple health complications and sometimes result in patient death. Therefore, maintaining muscle health is crucial for individuals undergoing dialysis. We recently reported that personalized resistance-based exercise can improve frailty in dialysis patients; however, the molecular mechanisms underlying its effects on muscle health remain unknown. RNA-Seq analysis revealed that exercise upregulates genes associated with muscle stemness, regeneration, and differentiation. Furthermore, our study demonstrated that exercise upregulates mitochondrial proteins involved in the oxidation of organic compounds and mitochondrial function in muscle. Moreover, we observed that exercise increased energy production via glucose uptake, glycogenesis, and fatty acid metabolism. These results suggest that personalized resistance-based muscle therapy in dialysis patients restores the expression of genes and proteins associated with muscle stemness, regeneration, differentiation, and energy generation.</p>

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Resistance-based exercise restores muscle health in dialysis patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月14日

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  • Piush Srivastava,
  • Sunil Kumar Singh,
  • Rakesh Sathish Nair,
  • Saket Jha,
  • Navin Viswakarma,
  • Deepti Srivastava,
  • Greg Hachaj,
  • Stephen T. Bartlett,
  • Ilaria Santi,
  • Aslam Ejaz,
  • Robert W. Motl,
  • Enrico Benedetti,
  • Sandeep Kumar,
  • Ajay Rana

摘要

Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are serious health concerns worldwide that require regular dialysis before a kidney transplant for a better quality of life. Due to aging and frailty, dialysis patients are often limited in physical activity, which can lead to multiple health complications and sometimes result in patient death. Therefore, maintaining muscle health is crucial for individuals undergoing dialysis. We recently reported that personalized resistance-based exercise can improve frailty in dialysis patients; however, the molecular mechanisms underlying its effects on muscle health remain unknown. RNA-Seq analysis revealed that exercise upregulates genes associated with muscle stemness, regeneration, and differentiation. Furthermore, our study demonstrated that exercise upregulates mitochondrial proteins involved in the oxidation of organic compounds and mitochondrial function in muscle. Moreover, we observed that exercise increased energy production via glucose uptake, glycogenesis, and fatty acid metabolism. These results suggest that personalized resistance-based muscle therapy in dialysis patients restores the expression of genes and proteins associated with muscle stemness, regeneration, differentiation, and energy generation.