<p>The flow of nanofluid and its behavior under thermal and electromagnetic influence presented significant attention because of widespread industrial and biomedical applications. The combined effect of thermal radiation and dissipative heat in electrically conducting Casson nanofluid flow is important in various optimizing processes likely polymer extrusion, thermal coating, etc. The present work aims to assess the impact of dissipative heat, such as the Joule and Darcy effects encourage the thermal properties of the Casson fluid. The Casson model is reported in presenting the non-Newtonian rheological properties accounting for yield stress behavior is observed in blood flow and polymeric suspension. The cross-diffusion between the solutal and thermal profile leading to the behavior of the Brownian and thermophoresis on the flow profiles. The design of the model obtained mathematically for the combination of the proposed factors and then the similarity transformation is utilized in transforming into the standard dimensionless form. Further, shooting-based Runge–Kutta is proposed in executing the solution of the model. The analysis of the proposed factors is reported graphically, and the comparative results are also shows good agreement with the earlier investigation. However, results indicate that increasing the Casson parameter reduces fluid velocity due to higher fluid resistance while both radiation and viscous dissipations encourage the thermal boundary layer thickness. Moreover, the heat transport rate intensifies for the interaction between electromagnetic forces and exponential stretching within the boundary region.</p>