Scholarlink

<p>In the case of acrylic bone cement, which polymerizes in the patient's body, the curing temperature cannot be too high, as this may cause necrosis of the surrounding tissues. Furthermore, bacterial infections occur during surgery due to the open pathway of infection. Therefore, solutions are being sought to mitigate these negative effects of necessary surgical procedures. Considering previous studies indicating that eugenol, a natural antibacterial agent, affects the curing process of bone cement by lowering its temperature (while negatively impacting the curing process itself) and imparting antibacterial properties, it was decided to modify it to eliminate negative effect on the curing process of bone cement. Thus, functional groups were introduced into the structure of eugenol, which can participate in the polymerization process of methacrylates and covalently bind it to the cement. Eugenol derivatives were obtained via esterification with methacrylic acid (EU-MAA) and by hydrothiolation with 2,2′-(ethylenedioxy)diethanethiol (EU-T2), and were used as modifiers for bone cement. The influence of modifiers on the polymerization kinetics was investigated by differential scanning calorimetry. Characterization of doughing time, maximum temperature, setting temperature and setting time, along with compressive strength tests were conducted in compliance with ISO 5833:2002. A significant decrease in the maximum temperature during the curing process of the modified bone cements was observed and, importantly, other parameters of the bone cement are in accordance with the standard. Furthermore, the eugenol derivatives show enhanced antibacterial efficacy and a broader spectrum of activity than eugenol, and the materials modified with them exhibited excellent antibacterial properties.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Can the addition of antibacterial eugenol derivatives lower the setting temperature of bone cement?

  • 期刊论文

  • 发表日期：

    2026年4月24日

查看全文
  • Grzegorz Przesławski,
  • Katarzyna Szcześniak,
  • Łukasz Popenda,
  • Piotr Gajewski,
  • Wojciech Smułek,
  • Agnieszka Marcinkowska

摘要

In the case of acrylic bone cement, which polymerizes in the patient's body, the curing temperature cannot be too high, as this may cause necrosis of the surrounding tissues. Furthermore, bacterial infections occur during surgery due to the open pathway of infection. Therefore, solutions are being sought to mitigate these negative effects of necessary surgical procedures. Considering previous studies indicating that eugenol, a natural antibacterial agent, affects the curing process of bone cement by lowering its temperature (while negatively impacting the curing process itself) and imparting antibacterial properties, it was decided to modify it to eliminate negative effect on the curing process of bone cement. Thus, functional groups were introduced into the structure of eugenol, which can participate in the polymerization process of methacrylates and covalently bind it to the cement. Eugenol derivatives were obtained via esterification with methacrylic acid (EU-MAA) and by hydrothiolation with 2,2′-(ethylenedioxy)diethanethiol (EU-T2), and were used as modifiers for bone cement. The influence of modifiers on the polymerization kinetics was investigated by differential scanning calorimetry. Characterization of doughing time, maximum temperature, setting temperature and setting time, along with compressive strength tests were conducted in compliance with ISO 5833:2002. A significant decrease in the maximum temperature during the curing process of the modified bone cements was observed and, importantly, other parameters of the bone cement are in accordance with the standard. Furthermore, the eugenol derivatives show enhanced antibacterial efficacy and a broader spectrum of activity than eugenol, and the materials modified with them exhibited excellent antibacterial properties.