Scholarlink

<p>The phase diagram, physicochemical and thermodynamic studies of newly synthesized co-crystals formed by the complexation in two organic pharmaceutical compounds namely nicotinamide (NIC)—3-nitrobenzoic acid (NBA) and sulfanilamide (SUL)—3-hydroxy-4-methoxybenzaldehyde (HMB) are reported. The individual phase diagram forming the co-crystals has been established. A phase diagram is a significant study to find the precise stoichiometric ratio at which the formation of new molecular complex/co-crystal would take place. The solvent-free solid-state synthesis method has been adopted for the synthesis of binary compounds in the entire range of compositions. The two novel co-crystals formed at 2:1 molar ratio in NIC–NBA and 1:1 molar ratio in SUL–HMB system along with two eutectics on either side of the co-crystal. The pure and single-phase behaviour of co-crystals and their melting are studied using the DSC method. The DSC of eutectics formed in both systems is also studied. Using the experimental heat of fusion values, obtained from DSC, various thermodynamic parameters of co-crystals and eutectics have been studied and are being reported first time. Besides the phase diagram and DSC studies, FTIR, PXRD and UV–Vis is absorption and emission studies also confirm the formation of co-crystals and change in their structures in comparison with that of the parent components.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phase diagram, thermal, structural and optical studies of newly synthesized co-crystals

  • 期刊论文

  • 发表日期：

    2026年3月1日

查看全文
  • Sumit Chaudhary,
  • Rama Nand Rai

摘要

The phase diagram, physicochemical and thermodynamic studies of newly synthesized co-crystals formed by the complexation in two organic pharmaceutical compounds namely nicotinamide (NIC)—3-nitrobenzoic acid (NBA) and sulfanilamide (SUL)—3-hydroxy-4-methoxybenzaldehyde (HMB) are reported. The individual phase diagram forming the co-crystals has been established. A phase diagram is a significant study to find the precise stoichiometric ratio at which the formation of new molecular complex/co-crystal would take place. The solvent-free solid-state synthesis method has been adopted for the synthesis of binary compounds in the entire range of compositions. The two novel co-crystals formed at 2:1 molar ratio in NIC–NBA and 1:1 molar ratio in SUL–HMB system along with two eutectics on either side of the co-crystal. The pure and single-phase behaviour of co-crystals and their melting are studied using the DSC method. The DSC of eutectics formed in both systems is also studied. Using the experimental heat of fusion values, obtained from DSC, various thermodynamic parameters of co-crystals and eutectics have been studied and are being reported first time. Besides the phase diagram and DSC studies, FTIR, PXRD and UV–Vis is absorption and emission studies also confirm the formation of co-crystals and change in their structures in comparison with that of the parent components.