<p>This study aims to optimize the energy performance of a solar-powered solid desiccant cooling system designed for the thermal conditioning of a 100 m² meeting room accommodating up to 50 occupants. The analysis is conducted for two contrasting climatic regions in Morocco: Casablanca (temperate and humid) and Marrakech (hot and semi-arid). The primary objective is to reduce the required surface area of the solar air collectors (SAC), while maintaining acceptable indoor thermal comfort. To achieve this objective, three optimization techniques are implemented and compared with the reference system configuration. The first technique consists in recirculating the heat released from the desiccant wheel’s regeneration side to preheat the inlet regeneration airflow. The second technique aims to enhance the desiccant wheel’s performance by pre-cooling the ambient airflow before the dehumidification process. Finally, a hybrid approach combining both the first and second techniques is explored. The results demonstrate significant performance improvements in both climates, particularly for Configuration 3. In this configuration, the SAC size is reduced by 32.53% in Casablanca and by 56.22% in Marrakech, while the thermal COP reaches 0.63 and 1.11, respectively. These findings confirm the effectiveness of the proposed optimization strategies for enhancing the feasibility of solar desiccant cooling systems in diverse Moroccan climatic conditions.</p>