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<p>The possible obstacle met when studying thermal properties of organic compounds is chemical decomposition. It can be avoided by minimizing the time spent at elevated temperatures, in particular, by applying fast heating rates. In this study, we used fast scanning calorimetry (FSC) to measure liquid state heat capacity and saturated vapor pressures of the thermally unstable drug carbamazepine that decomposes around its melting point. Combining these measurements with the literature data, differential scanning calorimetry, solution calorimetry, and statistical thermodynamics, we obtained a self-consistent dataset of the thermodynamic properties of phase transitions between two crystalline modifications, I and III, liquid, supercooled liquid, and gaseous carbamazepine in a wide temperature range between 298 and 470&#xa0;K.</p>

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Phase transition thermodynamics of carbamazepine below its decomposition temperature

  • 期刊论文

  • 发表日期：

    2025年12月14日

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  • Dmitrii N. Bolmatenkov,
  • Ilyas I. Nizamov,
  • Andrey A. Sokolov,
  • Airat A. Notfullin,
  • Boris N. Solomonov,
  • Mikhail I. Yagofarov

摘要

The possible obstacle met when studying thermal properties of organic compounds is chemical decomposition. It can be avoided by minimizing the time spent at elevated temperatures, in particular, by applying fast heating rates. In this study, we used fast scanning calorimetry (FSC) to measure liquid state heat capacity and saturated vapor pressures of the thermally unstable drug carbamazepine that decomposes around its melting point. Combining these measurements with the literature data, differential scanning calorimetry, solution calorimetry, and statistical thermodynamics, we obtained a self-consistent dataset of the thermodynamic properties of phase transitions between two crystalline modifications, I and III, liquid, supercooled liquid, and gaseous carbamazepine in a wide temperature range between 298 and 470 K.