<p>The objective of this research is to investigate the heat transfer mechanism of Casson fluid flow through a semi-porous curved channel with two distinct wall temperature conditions: constant wall temperature (CWT) and prescribed surface temperature (PST). Furthermore, the entropy generation is analyzed based on contributions from heat transfer irreversibility, viscous dissipation, and Joule heating. The motivation for this research stems from the necessity to control entropy production in thermally active curved porous channel, where chaotic instabilities lead to excessive energy loss and reduced operational efficiency. The governing equations are converted into systems of ordinary differential equations through the application of similarity variables. The solution of a coupled system of ordinary differential equations is computed with a bvp5c in MATLAB. The influence of various physical parameters on entropy analysis, including Bejan number, concentration, and velocity/temperature, is depicted and examined through graphical representations. The results showed that an increase in the Brinkman number increases the entropy generation rate, whereas the Casson parameter exhibits the opposite tendency. The rising values of the Brinkman number and temperature ratio parameter decrease the Bejan number. The analysis revealed that the heat transfer rate was more significant in the CWT compared to the PST, whereas the entropy exhibited an increase in the PST.</p>