<p>The fluid flow model is investigated for mass and energy transport using a hybrid nanofluid over an expanding surface. The nanofluid’s effectiveness, stability, and performance are improved by incorporating nanoparticles with distinct thermal and rheological properties. This hybrid nanofluid consists of titanium oxide (TiO₂) and cobalt ferrite (CoFe₂O₄) nanoparticles suspended in water. The study explores the intricate interactions between magnetohydrodynamics (MHD), thermal radiation, and porous media, which are relevant in various engineering applications. Additionally, the model accounts for the slip effect, thermal and mass convective boundary conditions, Joule heating, and Arrhenius activation energy. By applying similarity transformations, the original mathematical model is converted into a dimensionless form. The numerical solution is obtained using MATLAB’s built-in bvp4c function. The velocity profile decreases with increasing values of the magnetic and porosity parameters. An increase in Schmidt number, chemical reaction, and temperature difference parameters reduces the concentration profile. The thermal radiation, heat source, and Biot numbers influence the thermal profile. The heat transfer rate increases with higher radiation parameters, Eckert number, and Biot number, but decreases with the heat source. The Sherwood number intensified with the higher values of Schmidt number, chemical reaction and concentration Biot number. The skin friction improves with the slip parameter, while it diminishes with the magnetic field and porosity parameters. The present results show good agreement with previously published findings, validating the accuracy of the current model.</p>