<p>The SYSTAG calorimeter FlexyTSC SEDEX is utilized in Novartis safety laboratories to screen the thermal stability of reaction mixtures in pharmaceutical synthetic processes. In order to improve the accuracy of SEDEX calorimetric tests, a customized calibration method was developed specifically for the application scenarios of the calorimeter within our laboratories. During the check test of the new calibration method, it is no longer to detect the endothermic enthalpies of the melting process of reference solids, but to detect a known electrical power input through a heating resistor inserted into the silicone oil within the autoclave (sample cell) under continuous stirring. The check test conditions closely mirror those of the actual tests performed on chemical reaction mixtures. The new calibration method not only significantly improves the accuracy of the SEDEX test for detecting exothermic heat but also enhances the efficiency of the calibration process. It provides a valuable model for optimizing existing calibration schemes or developing new ones for calorimeters in safety laboratories based on their practical applications. In developing this calibration method, the reaction calorimeter (RC1) was used to validate the electrical energy output of the heating resistor, while the differential scanning calorimeter&#xa0;(DSC) was employed for cross-validation after the calibration of SEDEX. This endeavor exemplifies how we can make full use of the advantages of various calorimetric technologies in a safety laboratory to effectively address specific issues, that is crucial for a safety laboratory engineer when designing safety experiments appropriately to analyze thermal risks.</p>