In the present manuscript, impact of thermal radiation and heat generation on mixed convection heat and mass transfer flow of \({\text{Cu}}\) -water nanofluid from a permeable stretchable cylinder embedded in porous medium under the influence of the chemical reaction and convective boundary conditions is examined. The Darcy model is used for the porous medium. The partial differential equations describing flow of \(\text{Cu}\) -water nanofluid along with related boundary conditions are changed into a system of nonlinear ordinary differential equations by use of appropriate similarity transformations. The Runge–Kutta–Fehlberg fourth–fifth-order method is employed to handle resultant system of ordinary differential equations. The effect of various governing parameters on the velocity, temperature and concentration profiles as well as on the skin-friction coefficient, heat and mass transfer rates has been explored. Outcomes demonstrate that nanofluid temperature boosts with increasing heat source and thermal radiation parameters. Increasing porous medium and suction parameters caused increase in velocity profile. The output of increasing variations of chemical reaction and suction parameters is to improve the rate of mass transfer. The current work is novel in incorporating heat source, thermal radiation and convective boundary conditions in energy equations coupled with chemical reaction.