<p>A theoretical study is carried out on the MHD peristaltic circulation of Casson nanofluid via a medium that is porous inside a nonuniform duct with Joule heating and thermal radiation. The impacts of combined mass/heat transmission are considered in this model with the electroosmosis enhancement. The mathematical approach linearizes basic flow equations employing high wavelength and low Reynolds number assumptions. The Poisson and Nernst-Planck equations are used to simulate the electroosmosis process. For the distribution of electric potential along the electron double layer, the Debye-Huckel assumption is applied. Analytical formulas for velocity, temperature, concentration profiles, and volumetric flow rate are provided for both the fluid and particle phases. The pump rate’s properties and friction force are established using numerical integration. The impact of the model’s different parameters is shown graphically in detail using the Mathematica program. It is worth mentioning that the increasing Casson parameter, Hartmann number, and medium permeability improve nanofluid velocity, temperature fields, and Sherwood number in the center of the tube but have a reverse influence on concentration profiles, skin friction coefficient, and Nusselt number. An increment in electroosmotic velocity causes a drop in the temperature profile, skin friction coefficient, and Nusselt number at tube center but a rise in nanofluid velocity, concentration profile, and Sherwood number. The current work has several biomechanical and engineering implications, including nanobot propulsion for medicinal usage and novel pump concepts for microfluidic chromatography, procedures for separating human skin, and corrosion mitigation in civil engineering.</p>