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<p>With the growing public health threat posed by antimicrobial resistance, there is an urgent need for alternative therapeutic strategies. In this context, we present the design of a biomimetic, sustainable Ajwa date seed (DS) extract with metallic nanoparticles for effective microbial eradication. Ajwa date seed (DS) extract, DS-functionalized titania nanoparticles (DS-TNPs), and DS-functionalized silica–titania nanocomposites (DS-STNC) were synthesized by the sol–gel route at 80 °C for antimicrobial analysis. The DS-STNC exhibited spherical morphology with a crystallite size of 7 nm and a pore radius of around 3 nm. A uniform element distribution and heterogeneous chemical bonding were obtained between DS components, TiO<sub>2</sub>, and SiO<sub>2</sub>. Antimicrobial assays against <i>Staphylococcus aureus (SA)</i> and <i>Escherichia coli (E. coli)</i> demonstrated DS-STNC’s good performance against <i>SA</i>. DS-STNC showed 81% protein denaturation suppression and maximum cell membrane disruption in <i>E. coli</i>, with low cytotoxicity up to 50 µg/mL and a MIC of 4 µg/mL. DS-STNC demonstrates a large therapeutic window and potential for antimicrobial therapies.</p><p></p>

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Mesoporous Ajwa date seed-silica-titania nanocomposites: a promising multifunctional material for enhanced antimicrobial, antioxidant, and cytotoxicity activities

  • 期刊论文

  • 发表日期：

    2026年2月5日

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  • Shumaila Islam,
  • Adil Alshoaibi,
  • Munirah F. Aldayel

摘要

With the growing public health threat posed by antimicrobial resistance, there is an urgent need for alternative therapeutic strategies. In this context, we present the design of a biomimetic, sustainable Ajwa date seed (DS) extract with metallic nanoparticles for effective microbial eradication. Ajwa date seed (DS) extract, DS-functionalized titania nanoparticles (DS-TNPs), and DS-functionalized silica–titania nanocomposites (DS-STNC) were synthesized by the sol–gel route at 80 °C for antimicrobial analysis. The DS-STNC exhibited spherical morphology with a crystallite size of 7 nm and a pore radius of around 3 nm. A uniform element distribution and heterogeneous chemical bonding were obtained between DS components, TiO2, and SiO2. Antimicrobial assays against Staphylococcus aureus (SA) and Escherichia coli (E. coli) demonstrated DS-STNC’s good performance against SA. DS-STNC showed 81% protein denaturation suppression and maximum cell membrane disruption in E. coli, with low cytotoxicity up to 50 µg/mL and a MIC of 4 µg/mL. DS-STNC demonstrates a large therapeutic window and potential for antimicrobial therapies.