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<p>This work aimed to synthesize borate bioactive glasses (BBGs) with the composition <i>x</i>(CoO/SrO)-(28-<i>x</i>)CaO-27Na<sub>2</sub>O-42B<sub>2</sub>O<sub>3</sub>-3P<sub>2</sub>O<sub>5</sub> utilizing the sol-gel process. In this research, cobalt (Co) and strontium (Sr) ions were co-doped in an equimolar ratio (1:1) at varying concentrations of <i>x</i> = 0, 1, 2, and 3 mol%. Various techniques were employed to explore the impact of Co and Sr doping on the structural, bioactive, and antibacterial properties of the prepared samples. The bioactivity of the glass samples was assessed based on their ability to form a hydroxyapatite layer (HA) after soaking in simulated body fluid (SBF) for time intervals of 0, 7, 14, and 21 days. The Co-Sr co-doped BBGs exhibited a positive effect on HA layer formation, which was confirmed through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Field emission scanning electron microscopy (FESEM) analysis. The pH values of SBF were measured using a benchtop microprocessor pH meter. An initial increase in pH was observed during the first three days, attaining a maximum value of 8.57. Subsequently, a gradual decrease was recorded, with the pH stabilizing at ~7.85 after 21 days. The antibacterial activity was assessed utilizing a well diffusion method. Among the various compositions, the sample named 1.5CoSr demonstrated the most significant antibacterial activity, exhibiting inhibition zones of 17 mm and 20 mm against <i>E. coli</i> and <i>S. aureus</i> bacteria, respectively. The study findings revealed that the 1.5CoSr sample can be considered an optimized glass composition, which is a promising candidate for bone tissue regeneration applications.</p> Graphical Abstract <p></p>

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Sol- gel synthesis and in-vitro studies of cobalt and strontium co-doped borate bioactive glass ceramics for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年9月7日

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  • M. A. Madshal,
  • Norah. T. S. Albogamy

摘要

This work aimed to synthesize borate bioactive glasses (BBGs) with the composition x(CoO/SrO)-(28-x)CaO-27Na2O-42B2O3-3P2O5 utilizing the sol-gel process. In this research, cobalt (Co) and strontium (Sr) ions were co-doped in an equimolar ratio (1:1) at varying concentrations of x = 0, 1, 2, and 3 mol%. Various techniques were employed to explore the impact of Co and Sr doping on the structural, bioactive, and antibacterial properties of the prepared samples. The bioactivity of the glass samples was assessed based on their ability to form a hydroxyapatite layer (HA) after soaking in simulated body fluid (SBF) for time intervals of 0, 7, 14, and 21 days. The Co-Sr co-doped BBGs exhibited a positive effect on HA layer formation, which was confirmed through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Field emission scanning electron microscopy (FESEM) analysis. The pH values of SBF were measured using a benchtop microprocessor pH meter. An initial increase in pH was observed during the first three days, attaining a maximum value of 8.57. Subsequently, a gradual decrease was recorded, with the pH stabilizing at ~7.85 after 21 days. The antibacterial activity was assessed utilizing a well diffusion method. Among the various compositions, the sample named 1.5CoSr demonstrated the most significant antibacterial activity, exhibiting inhibition zones of 17 mm and 20 mm against E. coli and S. aureus bacteria, respectively. The study findings revealed that the 1.5CoSr sample can be considered an optimized glass composition, which is a promising candidate for bone tissue regeneration applications.

Graphical Abstract