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<p>The proliferation, differentiation or viability of cells on a bioactive surface such as ß-tricalcium phosphate (ß-TCP) is a key aspect of regenerative medicine and biomaterials research. In this study, a sol-gel solution specifically developed for biomaterial applications was used, into which crystalline ß-tricalcium phosphate (ß-TCP) powder was added at various concentrations. This approach differs from conventional methods where ß-TCP is synthesized directly within the sol–gel matrix. The direct incorporation of powder into the base sol allows for better control over particle distribution and size, influencing the morphology, mechanical properties, and biological activity of coatings applied to titanium substrates. The surfaces were characterized in terms of changes in roughness, wettability, and mechanical parameters. Biological tests with the MG63 cell line showed increased cell proliferation and adhesion, particularly during the first 48 h of cultivation, confirming the bioactive effect of the added ß-TCP powder. These results suggest the potential of this approach for developing bioactive coatings on titanium implants with improved osseointegration and stability.</p><p></p>

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Characterization and bioactivity of β-tricalcium phosphate powder sol–gel coatings on titanium substrates

  • 期刊论文

  • 发表日期：

    2025年9月15日

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  • Zdenek Tolde,
  • Vojtěch Smola,
  • Eva Šebová,
  • Zuzana Budinská,
  • Jakub Bumba,
  • Petr Vlčák

摘要

The proliferation, differentiation or viability of cells on a bioactive surface such as ß-tricalcium phosphate (ß-TCP) is a key aspect of regenerative medicine and biomaterials research. In this study, a sol-gel solution specifically developed for biomaterial applications was used, into which crystalline ß-tricalcium phosphate (ß-TCP) powder was added at various concentrations. This approach differs from conventional methods where ß-TCP is synthesized directly within the sol–gel matrix. The direct incorporation of powder into the base sol allows for better control over particle distribution and size, influencing the morphology, mechanical properties, and biological activity of coatings applied to titanium substrates. The surfaces were characterized in terms of changes in roughness, wettability, and mechanical parameters. Biological tests with the MG63 cell line showed increased cell proliferation and adhesion, particularly during the first 48 h of cultivation, confirming the bioactive effect of the added ß-TCP powder. These results suggest the potential of this approach for developing bioactive coatings on titanium implants with improved osseointegration and stability.