Exploring the multifunctionality of co-doped (Zn,Co)-CuO nanoparticles through biological activities, photodegradation, and biotoxicity assessment
摘要
This study presents the synthesis, characterization, and multifunctional evaluation of copper oxide (CuO) nanoparticles doped with zinc (Zn), cobalt (Co), and codoped with both (Zn,Co) using a co-precipitation method. Structural and morphological characterizations were conducted using XRD, FTIR, SEM, UV-Vis DRS, and EDX analysis, confirming the successful doping and formation of monoclinic CuO nanostructures. Antibacterial assays revealed enhanced activity for (Zn,Co)-CuO nanoparticles, with IC₅₀ values as low as 0.45 mg/mL against Klebsiella pneumoniae, indicating superior efficacy due to synergistic metal ion incorporation. DPPH scavenging and albumin denaturation assays demonstrated potent antioxidant and anti-inflammatory properties, with (Zn,Co)-CuO outperforming even standard references. Furthermore, (Zn,Co)-CuO exhibited the highest insecticidal activity (97.75% inhibition) and minimal phytotoxicity, making it a promising biocompatible agent. Photocatalytic degradation studies confirmed the superior efficiency of (Zn,Co)-CuO (91% Eriochrome black T degradation, k = 0.030 min−1), attributed to enhanced charge separation and active surface sites. These results collectively highlight the multifunctional potential of (Zn,Co)-CuO nanoparticles in biomedical, agricultural, and environmental applications.